皮肤鳞状细胞癌和基底细胞上皮瘤膜型基质金属蛋白酶-1、基质金属蛋白酶-2表达  

Expression of Membrane Type 1 Matrix Metalloproteinase and Matrix Metalloproteinase-2 in Cutaneous Squamous Cell Carcinoma and Basal Cell Epithelioma

作　　者：马泽粦[1] 樊翌明[1] 吴志华[1] 李顺凡[1] 

机构地区：[1]广东医学院附属医院皮肤科,湛江524001

出　　处：《中华皮肤科杂志》2004年第10期584-586,共3页Chinese Journal of Dermatology

基　　金：湛江市科技攻关项目(湛科[2003]69-7)

摘　　要：目的探讨皮肤鳞状细胞癌(简称鳞癌)和基底细胞上皮瘤(简称BCE)膜型基质金属蛋白酶-1(MT1-MMP)、基质金属蛋白酶-2(MMP-2)表达及其与临床病理特征的关系。方法应用原位杂交和ABC免疫组化技术检测48例皮肤鳞癌和41例BCE手术切除标本中MT1-MMP、MMP-2表达。结果鳞癌中MT1-MMP、MMP-2表达明显高于BCE(P<0.05),且二者的表达呈显著正相关(r=0.370,P<0.05)。MT1-MMP表达在高分化或伴有淋巴结转移的鳞癌中明显上调(P<0.05),而MMP-2表达增加仅见于伴有淋巴结转移的鳞癌(P<0.05)。鳞癌和BCE中MT1-MMP、MMP-2表达与患者性别、年龄、病程、发病部位、原发/转移病灶及BCE侵袭性无关(P>0.05)。结论MT1-MMP、MMP-2表达上调与皮肤鳞癌的淋巴结转移有关。MT1-MMP、MMP-2表达水平不能区别BCE是否具有侵袭性。Objective To observe expression of membrane-type 1 matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) and its relation to clinicopathological characteristics in cutaneous squamous cell carcinoma (SCC) and basal cell epithelioma (BCE). Methods The expression of MT1-MMP and MMP-2 was determined in situ hybridization and ABC immunohistochemical technique respectively in 48 cutaneous SCCs and 41 BCEs. Results The expression of MT1-MMP and MMP-2 in SCC was significantly higher than that in BCE (P < 0.05) marked correlation was found between the expression of MT1-MMP and MMP-2 (r = 0.370, P < 0.05). The expression of MT1-MMP was significantly higher in SCC with lymph node metastasis or well-differentiated SCC (P < 0.05). But an evident up-regulation of MMP-2 was only found in SCC with lymph node metastasis (P < 0.05). There was no any correlation between the expression of MT1-MMP and MMP-2 and the clinical features, such as sex, age, course of disease, tumor-site, primary or metastatic tumors and aggressiveness of the tumor (P > 0.05). Conclusions Overexpression of MT1-MMP and MMP-2 might be related to lymphatic metastasis in SCC. Expression levels of MT1-MMP and MMP-2 may not be responsible for the differentiation in aggressiveness of BCE.

关 键 词：MT1-MMP 表达 基质金属蛋白酶-2(MMP-2) 鳞癌 基底细胞 基质金属蛋白酶-1 皮肤鳞状细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]