AD7C-NTP基因的染色体定位及其产物的跨膜区预测  

The chromosomal location of AD7C-NTP gene and the prediction of transmembrane domains of its deduced protein

作　　者：桂俊豪[1] 刘家云[2] 贾林涛[2] 仇东辉[1] 余伍忠[1] 何江[1] 

机构地区：[1]兰州军区乌鲁木齐总医院临床医学研究所,新疆乌鲁木齐830000 [2]第四军医大学生物化学与分子生物学教研室,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2004年第5期604-607,共4页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的 :对AD7C NTP基因进行染色体定位 ,预测其编码产物的跨膜区。方法 :用Blat服务器进行AD7C NTPmRNA序列与基因组DNA序列的比对。借助PHDhtm、TMHMM2 .0、HMM TOP2 .0、SMART和PSORT等服务器 ,预测AD7C NTP基因编码产物的跨膜特征及其亚细胞定位。结果 :AD7C NTP基因定位于 1p36 .11负链 ,无内含子序列。AD7C NTP基因编码产物具有 3个跨膜区 ,可能定位于过氧化物酶体。结论 :对AD7CAIM: To characterize the chromosomal location of AD7C-NTP gene and predict the transmembrane domains and sub-cellular location of its deduced protein. METHODS: The AD7C-NTP mRNA sequence was alignmented with human genomic DNA sequence by Blat server. The transmembrane domains and sub-cellular location of AD7C-NTP protein were predicted by using PHDhtm, TMHMM2.0, HMMTOP2.0, SMART and PSORT servers, etc. RESULTS: The AD7C-NTP gene located in minus strand of 1p36.11, without intron. The AD7C-NTP protein was predicted to have 3 potential transmembrane domains and locate on peroxisome’s membrane. CONCLUSION: Bioinformatics analysis of the AD7C-NTP gene and its deduced protein provides valuable clues for further gene cloning and study of function.

关 键 词：生物信息学 AD7C-NTP基因 蛋白质 定位 跨膜区 预测 

分 类 号：R741[医药卫生—神经病学与精神病学]