远交群体动态性状基因定位的似然分析 Ⅰ.理论方法  

Maximum Likelihood Analysis for Mapping Dynamic Trait QTL in Outbred PopulationⅠ.Methodology

作　　者：杨润清[1] 高会江[2] 孙华[2] Shizhong Xu 

机构地区：[1]上海交通大学农业与生物学院,上海201101 [2]东北农业大学动物科学技术学院,哈尔滨150030 [3]DeptermentofBotany&PlantScience,UniversityofCalifornia

出　　处：《Acta Genetica Sinica》2004年第10期1116-1122,共7页

摘　　要：受动物遗传育种中用来估计动态性状育种值的随机回归测定日模型思想的启发 ,将关于时间 (测定日期 )的Legendre多项式镶嵌在遗传模型的每个遗传效应中 ,以刻画QTL对动态性状变化过程的作用 ,从而建立起动态性状基因定位的数学模型。利用远交设计群体 ,阐述了动态性状基因定位的似然分析原理 ,推导了定位参数似然估计的EM法两步求解过程。结合动态性状遗传分析的特点和普通数量性状基因定位研究进展 。The quantitative traits whose phenotypic values change with time in life or other quantitative factors,were defined as dynamic traits.Based on the idea about random regression test-day model for estimating breeding values in animal evaluation,a mathematic model was constructed for mapping dynamic trait loci by using Legendre polynomials to model dynamic changes of each genetic effect.The Maximum likelihood analysis implemented via EM algorithm was used to estimate the parameters,including QTL position,fixed genetic regression effects for dynamic trait QTL mapping in outbred population.Compared with the existing method for dynamic trait mapping QTL,the new method presented here not only allowed to sample dynamic trait in disequillibrium way,but also can achieve to map dynamic traits QTL in any resource population by just one step.The further study on dynamic trait mapping QTL was theoretically discussed by incorporating genetic analysis of dynamic trait into general mapping QTL.

关 键 词：动态性状 基因定位 LEGENDRE多项式 极大似然法 

分 类 号：S813[农业科学—畜牧学]