3-氯丙二醇对大白鼠附睾形态学影响的动态观察  

The Dynamic Observation of the Effect by α-chlorohydrin on Epididymal Morphology of Rat

作　　者：罗善云[1] 刘薇茜[2] 陈敏诲[2] 

机构地区：[1]湖北医学院组胚教研室 [2]湖北医学院病毒研究所

出　　处：《湖北医学院学报》1993年第1期16-20,共5页

摘　　要：以20mg/kg 3-氯丙二醇给大白鼠灌服,每日1次,连续5日,之后取材作组织学观察,结果发现:首先诱起附睾管起始部管腔扩大,粘膜上皮变薄,静纤毛减少、变短;间质内血管数量增加,炎性细胞浸润。继而附睾管头部、体部和尾部由近及远,顺次出现上述相似形态学改变,但在其深度和累及面的广度上亦依次逐渐降低。提示:导致此种变化的因子可能主要来源于睾丸,存在于生殖管道腔液中,并沿其输出管道,作用于流经附睾管各部所接触的组织和细胞,破坏其形态结构的完整性,从而严重干扰其功能活动的进行。本文尚时3-氯丙二醇对大白鼠附睾作用的机理及其与抗生育作用的关系进行了讨论.The morphologic alterations of the epididymal initial segment of rat were induced firstly after ad- ministration with α-chlorohydrin (20 mg/kg·d,successive five times):The lumen of ductus epi- didymis enlarged;the epithium of the mucosus membrane became thin;stereocilia decreased in number and became shorter;in connective tissue around ductus epididymidis the blood vessele and inflammato- ry cells increased.In epididymal caput,corpus,and cauda the morphologic alterations were observat- ed one after another but they were lighter than in initial segment.These facts suggested that the factor induced the above-mentioned morphologic alterations may be from testis chiefly and was in epididymal plasma.It affected each epididymal segment along the lumen of epididymis to destroy the epididymal morphology and structure and cause the confusion of epididymal function.The mechanism of the ef- fect by α-chlorohydrin on rat epididymis and the relationship between this mechanism and the antifer- tility effect of α-chlorohydrin were discussed.

关 键 词：附睾 解剖学 氯醇类 药理学 

分 类 号：R965[医药卫生—药理学]