慢性充血性心力衰竭患者TNFα水平变化的临床意义  

Changes of TNF α level in patients with chronic congestive heart failure

作　　者：施有为[1] 杨静[1] 殷丽琼[1] 刘江潮[1] 

机构地区：[1]合肥市第一人民医院心内科,230061

出　　处：《安徽医学》2004年第5期374-375,共2页Anhui Medical Journal

摘　　要：目的　探讨慢性充血性心力衰竭 (CHF)患者TNFα的变化及临床意义。方法　CHF患者 3 6例 ,健康对照者 2 0例 ,空腹取静脉血 ,检测血清TNFα。结果　CHF组与对照组比较 ,TNFα水平明显增高 (P <0 .0 1)。CHF的亚组中 ,心功能Ⅱ、Ⅲ级组、Ⅳ级组的TNFα水平均明显高于正常对照组 (分别为P <0 .0 5 ,P <0 .0 1,P <0 .0 1)。结论　TNFα是心力衰竭的致病因素之一。CHF患者TNFα水平与心力衰竭的程度有关。Objective To investigate the change of tumor necrosis factor α(TNF α)level in patients with chronic congestive heart failure(CHF).Methods Thirty six cases with chronic congestive heart failure and twenty normal controls were studied.The fasting serum TNF α was detected.Results The level of TNF α in CHF group was significantly higher than that in control group(P<0.01)。The TNF α levels of heart function Ⅱ、Ⅲ and Ⅳ group were obviously higher than that of control group(P<0.05,P<0.01,P<0.01).Conclusions TNF α is one of etiological factors of the heart failure.There is relationship between the TNF α level and degree of heart failure.

关 键 词：TNFΑ CHF 患者 慢性充血性心力衰竭 临床意义 对照组 水平变化 结论 目的 方法 

分 类 号：R541.6[医药卫生—心血管疾病]