MPPT治疗神经免疫性疾病的心血管不良反应  

Cardiovascular adverse effects after methylprednisolone pulse therapy for neuroimmunolgical disease

作　　者：李凯[1] 王训[1] 胡纪源[1] 韩丽[1] 韩咏竹[1] 杨任民[1] 

机构地区：[1]安徽中医学院神经病学研究所附属医院,合肥230061

出　　处：《安徽医学》2004年第5期380-382,共3页Anhui Medical Journal

摘　　要：目的　观察和探讨大剂量甲基强的松龙冲击疗法 (MPPT)治疗神经免疫性疾病时的心血管不良反应及对策。方法　对 5 69例病人进行了 2 0 0 6例次的MPPT治疗 ,MP成人 1g/d ,儿童 2 0mg/ (kg·d)溶于 5 %葡萄糖注射液5 0 0ml中静脉缓滴 ,qd× 3～ 5d为一个疗程 ,对患者进行生命体征、心电图监测 ,观察心血管不良反应。 结果　MPPT治疗中 ,98例次患者出现胸闷、心慌、面部潮红等 ,46例次血压升高 ;110 1例次 ( 5 4.9% )出现各种异常心电图 ,其中 12 3例次为比较严重的心律失常。结论　MPPT过程中应严格控制输注速度 ,密切观测生命体征及心电图监测 ,对原有心律失常及老年患者慎用。Objective To observe the neural or cardiovascular adverse effects after high-dose intravenous methylprednisolone pulse therapy(MPPT)in patients with neuroimmunolgical disease,then discuss the resolvent.Methods 569 patients undertook 2006 case-times MPPT with intravenous methylprednisolone 1 g(for children 20 mg/kg body weight)per dose on each of 3-5 consecutive days in one course of treatment.The vital signs,continuous electrocardiograms monitoring and cardiovascular side-effects were observed throughout the period.Results During the MPPT therapy period,98 cases of suffocative,palpitations,flushing and 46 cases of hypertension were observed;1101(54.9%)cases showed various arrhythmias including 123 cases of severe arrhythmias during the course of therapy.Conclusion It is very important to control infusion speed and monitor electrocardiographic(ECG)throughout the MPPT;Be cautious of using it in patients with arrhythmia and aged patients.

关 键 词：治疗 心血管不良反应 神经免疫性疾病 心电图监测 生命体征 患者 心律失常 疗程 输注速度 慎用 

分 类 号：R741[医药卫生—神经病学与精神病学]