血管平滑肌细胞增殖和迁移的信号传导调控及其研究进展  

Advances in Research on Modulation of Signal Conduction of Proliferation and Migration of Vascular Smooth Muscle Cell

作　　者：赵荫涛[1] 汪培华[1] 汪道文[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院心血管病研究室暨基因治疗中心,湖北武汉430030

出　　处：《心血管病学进展》2004年第5期390-393,共4页Advances in Cardiovascular Diseases

摘　　要：动脉中膜平滑肌细胞向内膜的迁移和增殖 ,在动脉粥样硬化和经皮腔内冠状动脉成行术 (PTCA)术后再狭窄等发病机制中起着重要作用。其在增殖和迁移过程中受蛋白激酶C、Ca2 + /钙调蛋白依赖性蛋白激酶Ⅱ、磷脂酰肌醇3 激酶 /蛋白激酶B、丝裂原激动蛋白激酶等多种信号传导通路调节。本文就血管平滑肌细胞 (VSMC)增殖和迁移的这些信号传导通路及其治疗的最新研究进展作一综述。Vascular smooth muscle cell migration from media of artery to intima and proliferation,play important role in the pathogenesis of atherogenesis,restenosis after percutaneous transluminal coronary angioplasty (PTCA) etc.VSMC can be modulated by several signal conducting pathways of PKC,CAM KinaseⅡ,PI 3-K/AKT and MAPK among proliferation and migration.We will review the recent research on these signal conducting pathways and therapies of proliferation and migration of VSMC.

关 键 词：血管平滑肌细胞增殖 信号传导通路 治疗 研究进展 VSMC 内膜 中膜平滑肌细胞 调控 丝裂原 蛋白激酶B 

分 类 号：Q253[生物学—细胞生物学]