云母对胃黏膜保护作用机制研究  

Mechanisms of muscovite on gastric mucosal protective effect

作　　者：钱云[1] 姒健敏[1] 王良静[1] 陈淑洁[1] 朱有法[1] 

机构地区：[1]浙江大学邵逸夫临床医学研究所胃肠病实验室,浙江杭州310016

出　　处：《中国中药杂志》2004年第8期781-785,共5页China Journal of Chinese Materia Medica

摘　　要：目的 :探讨云母对胃黏膜保护作用的机制。方法 :采用大鼠慢性胃炎模型 ,分组给药治疗 2周后取其标本 ,观察其病理、超微结构 ,检测胃液pH值及血浆PGE2 水平。结果 :中、高剂量云母组大鼠一般情况、胃黏膜大体观、组织光镜及电镜下观察其表现接近正常 ,胃液pH值明显高于模型组 (P <0 .0 1) ,肠化率 (8例中 1例 )较模型组大鼠 (10例中 4例 )有所降低。而其中中剂量云母组大鼠经治疗后 ,血浆PGE2 水平明显上升 (P <0 .0 1)。结论 :云母可吸附于胃黏膜表面 ,促进黏液分泌、抑制和中和胃酸、减少炎细胞浸润、促进PGE2 合成、逆转肠上皮化生 。Objective: To explore the mechanisms of muscovite gastric mucosal protective effect . Method: Rat model of chronic gastritis were used. After gastric mucosal injury was induced, the rats were divided into 6 groups and were treated with different drugs. 2 weeks later, the tissue and blood samples were obtained and measured. Result: The general conditions, the observations under macroscopy,microscope and electron microscope of the middle and high dose of muscovite groups resembled those of the normal group. Their PH levels were higher than those of the model group, and the rates of intestinal metaplasia were lower, but the PGE_2 level of the middle dose of muscovite group was the highest. Conclusion: Muscovite can be adsorbed on the surface of the gastric mucosa. It has gastric mucosal protective effect by improving excretion of mucus and synthesis of PGE_2 in gastric mucosa, restraining gastric acid, reversing of intestinal metaplasia and decreasing inflammation cells.

关 键 词：大鼠 胃黏膜保护 PGE2 胃液 血浆 作用机制 肠上皮化生 云母 可吸附 合成 

分 类 号：R285.5[医药卫生—中药学]