Lung cancer(LC)is the leading cause of cancer-related death worldwide,with non-small cell lung cancer(NSCLC)comprising 85%of all cases.COX-2,an enzyme induced significantly under stress conditions,catalyzes the conver...
supported,in part,by Natural Science Foundation of China(T2341004,82321004,82374558,82074511,81973660);the National Key Research and Development Program of China(2022YFE0206200 and 2023YFC2414500);Guangdong Basic and Applied Basic Research Foundation(2021B1515120023,China);Guangzhou Basic and Applied Basic Research Foundation(2024A04J4020,China).
Pyroptosis typically features the perforation of cell membranes,a process triggered by the exposure of active N-terminal domain of Gasdermin D(GSDMD).This pivotal event subsequently leads to the release of pro-inflamm...