New functions of oxylipins released by pyroptotic cells  

作　　者：Hui Xu Hong-Li Tan Hua-Jun Wang Xiao-Fei Zheng Yan-Ping Wu Rong-Rong He 

机构地区：[1]The First Affiliated Hospital,Guangdong Engineering Research Center of Traditional Chinese Medicine&Disease Susceptibility,Guangzhou Key Laboratory of Traditional Chinese Medicine&Disease Susceptibility,Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine,Guangdong Engineering Research Center of Traditional Chinese Medicine&Health Products,International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE),Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,State Key Laboratory of Bioactive Molecules and Druggability Assessment,Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs,Jinan University,Guangzhou 510632,China [2]State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第12期5509-5511,共3页药学学报（英文版）

基　　金：supported,in part,by Natural Science Foundation of China(T2341004,82321004,82374558,82074511,81973660);the National Key Research and Development Program of China(2022YFE0206200 and 2023YFC2414500);Guangdong Basic and Applied Basic Research Foundation(2021B1515120023,China);Guangzhou Basic and Applied Basic Research Foundation(2024A04J4020,China).

摘　　要：Pyroptosis typically features the perforation of cell membranes,a process triggered by the exposure of active N-terminal domain of Gasdermin D(GSDMD).This pivotal event subsequently leads to the release of pro-inflammatory cytokines,notably IL-1a and IL-1b,thereby fostering tissue inflammation and impeding the repair process 1.Moreover,the question of whether small molecule metabolites expelled through these pyroptotic pores possess specific physiological functions has consistently captivated the scientific community’s curiosity.A recent study published in Nature by Mehrotra et al.2 unveiled a novel paradigm,suggesting that oxygenated polyunsaturated fatty acids(oxylipins),released from pyroptotic cells,can paradoxically promote wound healing.This research demonstrates,as the famous saying goes,“From death comes rebirth”,innovatively revealing the interdependent relationship between cell death,inflammation,and repair.

关 键 词：Programmed cell death PYROPTOSIS OXYLIPINS PGE2 Tissue repair 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]