COX-2 in lung cancer:Mechanisms,development,and targeted therapies  

作　　者：Xueqi Liu Junli Zhang Wenwu Sun Jianping Cao Zhuang Ma 

机构地区：[1]Department of Respiratory Medicine,Postgraduate Training Base of Jinzhou Medical University in the General Hospital of Northern Theater Command,Shenyang,Liaoning,China [2]Department of Respiratory Medicine,General Hospital of Northern Theater Command,Shenyang,Liaoning,China

出　　处：《Chronic Diseases and Translational Medicine》2024年第4期281-292,共12页慢性疾病与转化医学（英文版）

摘　　要：Lung cancer(LC)is the leading cause of cancer-related death worldwide,with non-small cell lung cancer(NSCLC)comprising 85%of all cases.COX-2,an enzyme induced significantly under stress conditions,catalyzes the conversion of free arachidonic acid into prostaglandins.It exhibits high expression in various tumors and is closely linked to LC progression.COX-2 functions as a pivotal driver in cancer pathogenesis by promoting prostaglandin E2 synthesis and facilitating tumor cell occurrence and development.Furthermore,COX-2 holds potential as a predictive marker for early-stage NSCLC,guiding targeted therapy in patients with early COX-2 overexpression.Additionally,combining COX-2 inhibitors with diverse treatment modalities enhances tumor therapeutic efficacy,minimizes adverse effects on healthy tissues,and improves overall patient survival rates posttreatment.In conclusion,combined therapy targeting COX-2 presents a promising novel strategy for NSCLC treatment,offering avenues for improving prognosis and effective tumor treatment.This review provides novel insights and ideas for developing new treatment strategies to improve the prognosis of NSCLC.

关 键 词：COX-2 lung cancer PGE2 targeted therapy tumor development 

分 类 号：R734.2[医药卫生—肿瘤]