TBA联合PGE2对早期消化道出血的诊断价值分析  

Diagnostic Value of TBA Combined with PGE2 in Early Gastrointestinal Bleeding

作　　者：刘静 LIU Jing(Department of Hepatology,Spleen,and Gastroenterology,Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing,102800,China)

机构地区：[1]北京市昌平区中西医结合医院肝脾胃病科,北京102800

出　　处：《中华养生保健》2024年第23期42-45,共4页CHINESE HEALTH CARE

摘　　要：目的探讨总胆汁酸(TBA)联合前列腺素E2(PGE2)对早期消化道出血的诊断价值。方法选取北京市昌平区中西医结合医院2018年7月—2023年7月收治的105例消化道出血患者进行回顾性分析,所有患者均通过胃镜检查确诊,将患者依照出血量进行分组,将出血量<500 mL的患者分为轻度组(n=40),将出血量在800~1000 mL的患者分为中度组(n=25),将出血量>1500 mL的患者分为重度组(n=10)。另选取同期来北京市昌平区中西医结合医院体检的40名健康者作为对照组。对比四组受检者TBA、PGE2表达水平,分析TBA、PGE2与消化道出血严重性的相关性,并建立受试者特征(ROC)工作曲线分析TBA、PGE2对早期消化道出血的诊断临界值。结果四组患者TBA、PGE2表达水平对比,重度组TBA水平明显高于中度组、轻度组和对照组,PGE2水平明显低于中度组、轻度组和对照组(P<0.05);Spearman相关分析结果显示:TBA与消化道出血严重程度呈正相关(P<0.05),而PGE2与消化道出血严重程度呈负相关(P<0.05);TBA临界值取11.32μmol/L时,诊断指数达到最大值1.678,对早期消化道出血诊断的灵敏度为81.27%,特异性为79.46%。PGE2临界值取95.26 pg/mL时,诊断指数达到最大值1.689,对早期消化道出血诊断的灵敏度为84.95%,特异性为81.26%。结论TBA联合PGE2检测对提升早期消化道出血诊断率具有积极作用,且与消化道出血严重程度存在相关性,因此针对TBA>11.32μmol/L和PGE2<95.26 pg/mL的患者要警惕早期消化道出血的发生,并及时采取相关措施进行干预。Objective To investigate the diagnostic value of total bile acid(TBA)combined with prostaglandin E2(PGE2)in early gastrointestinal bleeding.Methods From July 2018 to July 2023,105 cases of patients with gastrointestinal bleeding in Beijing Changping District Hospital of Integrative Medicine were retrospectively analyzed.All patients were diagnosed by gastroscopy.Patients were grouped according to the amount of bleeding.Patients with a bleeding volume of<500 mL were divided into a mild group(n=40),patients with a bleeding volume of 800-1000 mL were divided into a moderate group(n=25),and patients with a bleeding volume of>1500mL were divided into a severe group(n=10).Another 40 healthy people who came to our hospital for physical examination during the same period were selected as the control group.The expression levels of TBA and PGE2 in the four groups were compared,and the correlation between TBA and PGE2 and the severity of gastrointestinal bleeding was analyzed.The receiver operating characteristic(ROC)curve was established to analyze the diagnostic threshold of TBA and PGE2 for early gastrointestinal bleeding.Results The expression levels of TBA and PGE2 in the severe group higher than those in the moderate group,mild group and control group,and the level of PGE2 was significantly lower than those in the moderate group,mild group and control group(P<0.05);Spearman correlation analysis showed that TBA was positively correlated with the severity of gastrointestinal bleeding(P<0.05),while PGE2 was negatively correlated with the severity of gastrointestinal bleeding(P<0.05);The critical value of TBA is 11.32μThe diagnostic index reached the maximum value of 1.678 at the concentration of 1.678 mol/L.the sensitivity and specifi city for the diagnosis of early gastrointestinal bleeding were 81.27%and 79.46%,respectively.When the critical value of PGE2 was 95.26 pg/mL,the diagnostic index reached the maximum value of 1.689,and the sensitivity and specifi city for the diagnosis of early gastrointestinal bleeding wer

关 键 词：总胆汁酸 前列腺素E2 早期消化道出血 灵敏度 特异度 

分 类 号：R573.2[医药卫生—消化系统]