猫脑缺血时脑不同位置血流变化的比较  

Comparison of Changes of Cerebral Blood Flow at Different Position in Cats with Brain Ischemia

作　　者：石广志[1] 张淑珍[2] 张绍东 罗芳[2] 翟晶 

机构地区：[1]首都医科大学附属北京天坛医院ICU [2]天坛医院麻醉科 [3]北京市神经外科研所

出　　处：《首都医科大学学报》2004年第3期326-328,共3页Journal of Capital Medical University

基　　金：北京市自然科学基金 ( 7992 0 2 1)资助项目

摘　　要：应用猫局灶性脑缺血模型 ,利用计算机控制的激光多普勒血流计 ,持续监测猫脑不同位置在脑缺血时的血流变化。结果 :阻断大脑中动脉 (MCA)后 ,猫脑颞叶和枕叶的脑血流迅速下降 ,分别为正常值的 2 1 .44%和 2 3 .61 % ;并在 2h内缓慢下降 ,最终分别为正常值的 1 5 .74%和 9.96% ,除 2h点外 ,二者无显著差异。提示 :猫局灶性脑缺血时 。The purpose was to observe the changes of cerebral blood flow at different position using the model of the cats with brain ischemia. The middle cerebral artery (MCA) of every cat was occluded after craniotomy firstly, The animals were divided into two groups monitoring cerebral blood flow (CBF) continuously by Laser Doppler flowmetry in two hours: Group 1 (n=6), at temporal cortex; Group 2 ( n=6), at occipital cortex. After the MCA was occluded, the CBF whether at temporal or at occipital cortex reduced quickly to 21.44% and 23.61% of the normal value consequently. The CBF decreased slowly in two hours and reduced to 15.74% and 9.96% at last. The CBF had no statistics difference in 0 h, 0.5 h, 1 h, 1.5 h, except at 2 h. The change of the CBF at temporal and occipital cortex has no statistics difference in cats with brain ischemia.

关 键 词：血流变化 局灶性脑缺血模型 颞叶 正常值 激光多普勒血流计 脑血流 大脑中动脉 显著差异 位置 提示 

分 类 号：R743[医药卫生—神经病学与精神病学] R742[医药卫生—临床医学]