川芎嗪对脑梗死患者内皮细胞功能影响的研究  

Effect of ligustrazine on the endothelial function in the patients with cerebral infarction

作　　者：李效敏 孙慧 赵勇[2] 孙金凤[3] 

机构地区：[1]禹城市人民医院,山东禹城251200 [2]济南市中心医院,250013 [3]山东省立医院,250021

出　　处：《中国急救医学》2004年第10期740-741,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨内皮素-1(ET-1)和一氧化氮(NO)在脑梗死发病过程中的病理生理意义及评价川芎嗪对脑梗死患者内皮功能的影响。方法用放射免疫分析法测定血浆ET-1,用酶联免疫吸附法测定血浆NO,用川芎嗪治疗一疗程后检测血浆ET-1和NO水平的变化。结果正常对照组血浆ET-1水平为4854±1025pg/mL,NO为3615±1231μmol/L;脑梗死组血浆ET-1水平为7638±2128pg/mL,NO为2804±1129μmol/L,与对照组比较ET-1显著升高,NO显著降低(P<005);脑梗死组经川芎嗪治疗后,血浆ET-1水平为5622±1312pg/mL,NO为4841±612μmol/L,与治疗前比较,血浆ET-1显著降低,NO显著升高(P<005)。结论脑梗死患者血浆ET-1和NO发生变化,川芎嗪可显著改善脑梗死患者的内皮功能。Objective To explore the pathophysiological significance of plasma endothelin and nitric oxide in the cerebral infarction and the effect of ligustrazine on the endothelial function in the patients with cerebral infarction. Methods The levels of plasma ET-1 were determined by radioimmunoassay and NO by ELISA. Results In healthy controls, the average level of plasma ET-1 was 48.54±10.25 pg/mL and that of NO was 36.15±12.31 μmol/L. In cerebral infarction cases, the average level of plasma ET-1 was 76.38±21.28 pg/mL and that of NO was 28.04±11.29 μmol/L. Compared with control group, the levels of plasma ET-1 were significantly higher and NO were remarkably decreased in patients group (P<0.05). After treatment with ligustrazine, the average level of ET-1 was 56.22±13.12 pg/mL and that of NO was 48.41±6.12 μmol/L in the patients. In comparison with the levels before the treatment, the levels of ET-1 were significantly decreased and NO were remarkably higher (P<0.05). Conclusion The level of plasma ET-1 are increased and that of NO are decreased in the patients with cerebral infarction. ligustrazine can improve the function of endothelium. [

关 键 词：脑梗死 川芎嗪 内皮素 一氧化氮 

分 类 号：R743.3[医药卫生—神经病学与精神病学]