茶多酚对大鼠心肌缺血再灌注诱导内皮细胞损伤的保护作用  

Protective effects of tea polyphenols on endothelial cell injury induced by myocardial ischemia reperfusion in rats

作　　者：郑运江[1] 杨浩[1] 汤圣兴[1] 韩金旺[1] 俞国华[1] 

机构地区：[1]皖南医学院附属弋矶山医院心血管内科,安徽芜湖241001

出　　处：《皖南医学院学报》2004年第4期245-247,共3页Journal of Wannan Medical College

摘　　要：目的　研究茶多酚对大鼠心肌缺血再灌注损伤内皮细胞的保护作用。方法　在大鼠左冠状动脉前降支结扎致心肌缺血再灌注损伤模型的基础上 ,观察茶多酚药物干预对损伤大鼠血浆中血管性血友病因子 (vWF)活性及脂质过氧化终产物丙二醛 (MDA)、一氧化氮 (NO)含量的影响。结果　茶多酚能明显降低血浆MDA含量、vWF活性及提高NO含量。结论　茶多酚对心肌缺血再灌注损伤内皮细胞有明显保护作用 。Objective To study the protective effects of tea polyphenols(TPs) on endothelial cells injury induced by myocardial ischemia reperfusion. Methods Observe the change of contents of malondiadehyde(MDA)、nitric oxide(NO) and the activity of von willebrand factor(vWF) in plasma among myocardial ischemia reperfusion injury models (IR)which performed via coronary artery left anterior descending(LAD) ligation and the change of them after tea polyphenols were intravenously injected. Results Compared with IR group,The level of MDA and vWF in plasma were significantly decreased in high and middle TPs groups (P<0.01) and the content of plasma NO was remarkably increased (P<0.01). Conclusion TPs has remarkable protective effects on endothelial cell injury induced by IR. Its mechanism may be related to scavenging oxygen free radicals,inhibiting lipid peroxidation,and increasing the content of NO.

关 键 词：大鼠 保护作用 心肌缺血再灌注损伤 茶多酚 内皮细胞损伤 NO含量 血浆 活性 产物 降低 

分 类 号：R285.5[医药卫生—中药学] R541[医药卫生—中医学]