TIMP-2在大肠癌中的表达及与血管生长的关系  

Antiangiogenic effects on TIMP-2 in colon cancer

作　　者：李先海[1] 夏祥厚[1] 吴佩[1] 阎竟一[1] 王亚兵[1] 

机构地区：[1]皖南医学院附属弋矶山医院普外科,安徽芜湖241001

出　　处：《皖南医学院学报》2004年第4期266-268,共3页Journal of Wannan Medical College

摘　　要：目的　研究基质金属蛋白酶抑制剂 (TIMP 2 )与大肠癌临床病理类型及血管生成的关系。方法　应用免疫组织化学S P法 ,分析 4 0例手术切除的新鲜大肠癌标本TIMP 2、CD34的表达。结果　TIMP 2在大肠癌癌组织中阳性表达率为 35 .0 % (14 / 4 0 ) ,低于癌旁组织的阳性率 [5 7.5 % (2 3/ 4 0 ) ];TIMP 2表达与大肠癌肿块浸润深度、转移和DUKES分期有显著差别 (P <0 .0 5 ) ,而与大肠癌分化程度无显著差别 (P >0 .0 5 ) ;MVD与肿块浸润深度、转移和DUKES分期有显著差别 (P <0 .0 5 ) ,但与组织分化程度无显著差别 (P >0 .0 5 )。MVD表达与TIMP 2表达呈明显负相关 (γs=- 0 .2 6 1,P <0 .0 5 ) .结论　TIMP 2在人体大肠癌组织中可通过抑制肿瘤血管的生长 ,参与大肠癌的生长、浸润、转移而在大肠癌的发生和演进中起到重要作用 .Objective To investigate antiangiogenic effects on TIMP-2 in colorectal carcinoma. Methods 40 cases of colorectal carcinoma patients were examined with immunohistochemical staining (S-P method)by using anti-TIMP-2 and anti-factor CD34(+) monoclonal antibodies. Results TIMP-2 was positive [57.5% (23/40)] in adjacent mucosa of colon cancer. That was higher than that in its primary foci [35.0%(14/40)] of colon cancer. TIMP-2 expression in primary foci was closely correlated with tumor invasive depth,metastasis and DUKES staging of colon cancer (P<0.05) despite showing no significant relationship between its expression and differentiation(P >0.05). The results suggested positive correlation of mean MVD with tumor depth of invasion,metastasis and DUKES staging(P <0.05),but no relationship was found between mean MVD and differentiation in colon cancer (P >0.05). A significant negative correlation was revealed between the TIMP-2 and MVD.Conclusion There is certain antagonist between the expression of MVD and TIMP-2 in human colon cancer. By interfering with the process of degradation of extracellular matrix and the angiogenesis,TIMP-2 plays an important role in growth,invasion,metastasis and angiogenesis in colon cancer .

关 键 词：大肠癌 TIMP-2 表达 肿块 DUKES分期 浸润深度 血管生长 负相关 标本 分化程度 

分 类 号：R735[医药卫生—肿瘤] R737[医药卫生—临床医学]