荷瘤鼠红细胞免疫粘附功能的初步研究  

A Preliminary Study on Red Cell Immune Function in Tumor-bearing Mice

作　　者：陈江[1,2] 王模堂 

机构地区：[1]福建医学院附属口腔医院 [2]华西医科大学口腔医学院

出　　处：《福建医学院学报》1994年第2期126-128,共3页

摘　　要：采用酵母多糖法分别检测早期和晚期Ｓ１８０肉瘤荷瘤小鼠的红细胞免疫粘附功能（ＲＣＩＡ），发现早期荷瘤鼠的红细胞Ｃ３ｂ受体活性下降，表面粘附的免疫复合物增多。晚期荷瘤鼠Ｃ３ｂ受体活性下降，红细胞表面粘附的免疫复会物减少，提示由于癌肿的存在影响小鼠的红细胞免疫状态，肿瘤早期机体的红细胞有一定的粘附清除免疫复合物的能力，随着肿瘤发展，红细胞Ｃ３ｂ受体活性受到严重的损害，最终导致机体红细胞免疫粘附能力低下。Blood from 40 tumor-bearing(S180)BALB/C mice was assayed for red cell immune adherence function by Saccharomycetic assay.The resuls show:the activity of C3b receptor on the surface of erythrocytes(E)was decreased in the mice at early stage of tumor-bearing,IC adherence on the surface of E is increased.In the mice at advanced stage of tumor-bearing,the activity of C3b receptor was contintuously inhibited,but IC adherence was decreased.This suggests that tumor lesion affects RCIA function of mice.At early stage of tumor,E has some capability of adherence and cleaning IC.While tumor lesion developing,activity of C3b receptor is depressed seriously.This results in decreased RCIA function.

关 键 词：荷瘤鼠 红细胞免疫粘附功能 早期 免疫复合物 红细胞C3B受体 晚期 肿瘤 活性 酵母多糖 下降 

分 类 号：R730[医药卫生—肿瘤] R285.5[医药卫生—临床医学]