急性脑血栓患者血浆溶血磷脂酸的研究  

A study of the plasma level of lysophosphatidic acid in patients with acute cerebral thrombosis

作　　者：高伟[1] 贾明珠[1] 朵振顺[2] 

机构地区：[1]临汾市人民医院,041000 [2]山西医科大学第一医院

出　　处：《山西医药杂志》2004年第10期839-842,共4页Shanxi Medical Journal

摘　　要：目的探讨急性脑血栓患者血浆溶血磷脂酸(LPA)的变化及与血糖、血脂、病变部位的关系。方法采用有机溶剂抽提及分光光度计定量分析法。结果急性脑血栓形成组LPA值高于正常对照组,分别为(4.0±1.7)、(1.0±0.6)μmol/L(P<0.005);合并血糖或血脂增高的急性脑血栓患者高于无血糖及血脂增高者,分别为(4.7±2.0)、(4.6±2.0)、(3.3±0.7)μmol/L(P<0.01)。结论LPA作为血小板活化程度的指示物,可指示脑血栓形成的启动,可对急性脑血栓作出预报,并证实早期血栓形成;LPA值的高低与血糖血脂有密切关系;皮层支血栓LPA值高于深穿支血栓,LPA值升高程度与脑血栓严重程度相关,可用来预测脑血栓患者的预后。Objective To study the plasma level of lysophosphatidic acid (LPA) in patients with acute cerebral thrombosis and its relationship with blood sugar, cholesterol and the parts of infarction. Methods Phospholipid acid was extracted from plasma of patients with cerebral thrombosis by organic solvent. The quantity of LPA was determined by spectrophotometry. Results LPA level of patients with acute cerebral thrombosis was (4.0±1.7) μmol/L; it′s higher than control group (1.0±0.6) μmol/L (P<0.005); LPA increased heavily in patients with high blood sugar (4.7±2.0) μmol/L and high cholesterol (4.6±2.0) μmol/L than the blood sugar and cholesterol normal group (3.3±0.7) μmol/L (P<0.01). Conclusion As a molecular marker released by activated platelets, LPA can forecast the ischemic shock, the increase of plasma LPA is related with blood sugar and cholesterol. The LPA level of cortical branch of cerebral arteries infarction is higher than that of central branch infarction. The higher the LPA rises, the more serious the patients condition is. So LPA can forecast the patients′ prognosis.

关 键 词：LPA 急性脑血栓 患者 血糖 血浆 溶血磷脂酸 血脂 抽提 皮层 分光光度计 

分 类 号：R743.3[医药卫生—神经病学与精神病学]