视网膜神经纤维层厚度测量与图形视网膜电图在开角型青光眼诊断与监测中的应用比较  

Comparing retinal nerve fiber layer thickness by OCT with P-ERG in the diagnosis and monitor of open-angle glaucoma

作　　者：王梅[1] 葛坚[2] 刘嫣芬[1] 蓝育青[1] 骆荣江[1] 郭慧[1] 

机构地区：[1]中山大学附属第二医院眼科,广州510120 [2]中山大学中山眼科中心

出　　处：《中国实用眼科杂志》2004年第10期788-790,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的　比较光学相干断层成像术 (OCT)测量视网膜神经纤维层 (RNFL)厚度与图形视网膜电图 (PERG)在开角型青光眼诊断与监测中的应用。方法　采用配对研究 ,同时对 2 6例(5 0眼 )开角型青光眼患者进行OCT与PERG检查 ,配对 χ2 检验比较二种检查在青光眼中的异常率 ,线性回归分析其间相关性。结果　青光眼环绕视乳头的RNFL平均厚度以及上、下象限的RNFL厚度与PERG振幅呈显著性相关 (P <0 0 5 )。OCT与PERG检查在青光眼早期中的异常率分别为 40 9%与 77 9% ,差异具有显著性意义 (P <0 0 5 ) ;在进展期与晚期中的异常率分别为 78 6%与 82 1% ,差异无显著性。结论　在青光眼的早期诊断中 ,OCT的敏感性低于PERG ;在进展期与晚期 ,OCT与PERG的敏感性无显著性差异。Objective To compare the diagnostic and monitoring ability of retinal nerve fiber layer(RNFL)thickness measured by optical coherence tomography(OCT)and pattern electroretinogram(PERG)in primary open-angle glaucoma(POAG).Methods In a cross-sectional clinical study,26 patients(50 eyes)with POAG were measured with OCT and PERG.The abnormal rates of OCT and PERG were compared by paired χ 2 test,and the correlation between RNFL thickness and PERG was investigated by linear regression analysis.Results In POAG eyes,the RNFL overall,superior and inferior thickness were significantly correlated with the PERG amplitude( P <0 05).The abnormal rate of quantification of the RNFL thickness was 40 9% at early stage of glaucoma,less than that of PERG(77 9%)significantly( P <0 05);and there were no significant difference between the abnormal rates of both methods at developing and late stage of glaucoma.Conclusions The sensitivity of OCT is lower than that of PERG in early diagnosis of glaucoma,there is a correlation between RNFL thickness and the amplitudes of PERG,quantification of RNFL thickness by OCT combined with PERG may be useful to early diagnosis and monitoring of POAG.

关 键 词：诊断 开角型青光眼 OCT 异常率 图形视网膜电图 监测 视网膜神经纤维层厚度 期中 显著性 结论 

分 类 号：R775[医药卫生—眼科] G633[医药卫生—临床医学]