丁二酸洛沙平与盐酸氯丙嗪治疗精神分裂症的对照研究  

A comparison study on loxapine and chlorpromazine in the treatment of schizophrenia

作　　者：薛士健[1] 黄金满[1] 杨铭哲[1] 

机构地区：[1]广东省广州市精神病医院,广东广州510370

出　　处：《中国民康医学》2004年第10期593-594,共2页Medical Journal of Chinese People’s Health

摘　　要：目的 :比较洛沙平与氯丙嗪治疗精神分裂症的疗效和副反应。 方法 :将符合CCMD— 3精神分裂症诊断标准的 10 0例门诊病人随机分成两组 ,分别采用丁二酸洛沙平与氯丙嗪治疗 ,疗程 8周 ,于治疗前及治疗后第 1、2、4、6、8周末分别以BPRS、TESS评定。 结果 :两组疗效相当 ,但丁二酸洛沙平作用起效快且持久 (低剂量时具有非典型抗精神病药特点 )。两组副反应基本相似。 结论Objective: To compare efficacy and side effects of loxapine and chlorpromazine in the treatment of schizophrenia. Methods: 100 Schizophrenic outpatients (diagnosed according to CCMD-3) were randomly assigned to receive loxapine or chlorpromazine treatment for 8 weeks, and rated with BPRS and TESS before and at the end of 1, 2, 4, 6 and 8 week of the treatment. Results: Similar efficacy and side effects were found in two groups, but faster onset and longer effect in loxapine group. Conclusions: Loxapine is indicated as a kind of safe and effective antipsychotics.

关 键 词：治疗 丁二酸洛沙平 精神分裂症 氯丙嗪 副反应 对照研究 疗效 结论 周末 特点 

分 类 号：R749[医药卫生—神经病学与精神病学] R735.7[医药卫生—临床医学]