现代电休克治疗激越行为对照研究  

A comparative study of the effect of modern electroconvulsive therapy on the agitated behavior of psychotic patients

作　　者：黄文升[1] 邸晓兰[1] 杨甫德[1] 牛亚娟[1] 吉中孚[1] 王向群[1] 

机构地区：[1]北京回龙观医院,100096

出　　处：《临床精神医学杂志》2004年第5期276-277,共2页Journal of Clinical Psychiatry

摘　　要：目的 :比较现代电休克治疗 (MECT)和氟哌啶醇注射治疗对急性激越患者的疗效以及对血清催乳素 (PRL)水平的影响。　方法 :6 0例伴有激越行为的急性期精神疾病患者 ,随机分成两组 ,MECT组 2 8例 ,氟哌啶醇组 32例 ,分别在入组前、治疗第 4天和第 7天采用阳性与阴性症状量表 (PANSS)的激越因子分以及临床总体印象量表 (CGI)评定疗效 ,副反应量表 (TESS)评定不良反应。使用酶联免疫吸附法测定血清PRL水平。　结果 :两组治疗后第 4天和第 7天的PANSS激越因子分、CGI总分均较疗前显著下降 ,第 7天时以MECT组显著较好。氟哌啶醇组在第 7天TESS总分显著高于MECT组 ,治疗第 7天比治疗前催乳素水平有显著提高。　结论 :MECT和氟哌啶醇注射治疗急性期兴奋患者的激越症状均有很好疗效。MECT的疗效、依从性、疗效指数更有优势 。Objective:To compare the effect of modern electroconvulsive therapy (MECT) and haloperidol injection on the agitation of acute psychotic patients and their serum prolactin levels. Method:Sixty acute and agitated psychotic patients were randomly divided into two groups with MECT (n=28) or haloperidol injection (n=32) respectively.All the patients were evaluated with the positive and negative syndrome scale (PANSS),the clinical global impression (CGI) and the treatment emergent symptoms scale (TESS) before treatment and at the 4th and 7th day after treatment. Each patient's serum prolactin level was tested with enzyme linked immunosorbent assay (ELISA). Results:Compared with the patients before treatment,the score of the agitation subscale of PANSS and the total scores of CGI in both groups were all significantly lower after treatment. In addition ,at the 7th day, these scores were significantly lower in MECT group than in haloperidol injection group,while the score of TESS was significantly higher in haloperidol injection group than in MECT group.In haloperidol injection group, mean serum prolactin level was remarkedly higher after treatment. Conclusion:It is suggested that MECT have good efficacy and compliance in the acute psychotic patients with agitated behavior,and only produce little side effects.

关 键 词：现代电休克治疗 氟哌啶醇 激越 催乳素 

分 类 号：R749.054[医药卫生—神经病学与精神病学]