雌激素受体在人类多激素型垂体腺瘤中的表达  

Expression of estrogen receptor in human plurihormonal pituitary tumor

作　　者：朱雨岚[1] 刘伟[1] 俞春江[1] 赵淑华[2] 

机构地区：[1]哈尔滨医科大学第二临床医学院神经内科,黑龙江哈尔滨150086 [2]哈尔滨医科大学保健科,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2004年第5期429-431,434,共4页Journal of Harbin Medical University

基　　金：黑龙江省留学归国人员基金课题 (LC0 0 0 5 )

摘　　要：目的　研究人类多激素型垂体腺瘤中雌激素受体 (ER)在分泌不同类型激素的垂体腺瘤细胞中的表达 ,探讨多激素型垂体腺瘤中分泌特定类型激素的垂体腺瘤细胞与ER阳性细胞的关系。方法　采用免疫组织化学双标法检测 33例多激素型垂体腺瘤标本中垂体激素合并ER表达的情况 ,即分别检测每 1例标本中PRL +ER、GH +ER、ACTH +ER、TSH +ER、FSH +ER和LH +ER的表达情况。结果　 33例多激素型垂体腺瘤标本中有 2 2例(6 6 .6 7% )表达ER ,其中PRL +ER双标染色阳性标本 10例、LH +ER双标染色阳性标本 9例、FSH +ER双标染色阳性标本 7例、GH +ER双标染色阳性标本 2例 ,33例标本的ACTH +ER和TSH +ER的双标染色均为阴性。结论　多激素型垂体腺瘤中 ,分泌PRL、LH或FSH的垂体腺瘤细胞可表达ER ;分泌ACTH或TSH的垂体腺瘤细胞不表达ER ;分泌GH的垂体腺瘤细胞是否表达ER可能与该垂体腺瘤是否同时分泌PRL有关。ER很可能在多激素型垂体腺瘤PRL、LH及FSH腺瘤细胞的发生、发展过程中发挥作用。Objective Different hormone-producing adenoma cells in plurihormonal pituitary tumors were exa- mined for estrogen receptor (ER) in order to study the relationship between the specific hormone-secreting adenoma cells and the ER-immunoreactive tumorous pituitary cells.Methods Immunohistochemical double-staining method was applied to detect the coexpression of ER and one specific pituitary hormone, in other words, to detect the coexpression of PRL and ER, GH and ER, ACTH and ER, TSH and ER, FSH and ER, LH and ER in 33 plurihormonal pituitary tumors, respectively. Results 33 plurihormonal pituitary tumors, ER protein was detected in 22 cases(66.67%). Among them, PRL and ER double staining were found in 10 specimens, LH and ER double staining were found in 9 specimens, FSH and ER double staining were found in 7 specimens, GH and ER double staining were found in 2 specimens. Double staining did not characterize the nuclear ER positivity in cells containing cytoplasmic reactivity for ACTH or TSH in 33 cases. Conclusion In plurihormonal pituitary tumors, the PRL, LH or FSH producing adenoma cells can express ER , while neither ACTH nor TSH producing adenomous cells express ER. Whether GH-secreting tumorous cells expressing ER attributes to the tumorous pituitary secreting PRL or not. ER plays an important role in the occurrence and development of the PRL, LH or FSH secreting adenomous cells in plurihormonal pituitary tumors possibly.

关 键 词：ER 垂体腺瘤 表达 瘤细胞 PRL 阳性标本 分泌 FSH 激素 GH 

分 类 号：R737[医药卫生—肿瘤] R736.4[医药卫生—临床医学]