胃癌E钙粘素和β-连环素的表达及其临床意义  

Expression and clinical significance of E-cadherin and β-catenin in gastric carcinoma

作　　者：张晓辉[1] 杜金荣[1] 韩丽姝[1] 付红[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院病理科,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2004年第5期435-438,F004,共5页Journal of Harbin Medical University

摘　　要：目的　探讨胃癌E钙粘素 (E cadherin ,E cad)和 β 连环素 (β catenin ,β cat)的表达及其临床意义。 方法　利用组织芯片技术 ,采用免疫组织化学 (S P)法检测 5 8例胃癌、2 0例胃腺瘤和 18例胃正常组织中E钙粘素和 β 连环素基因蛋白产物的表达水平。结果　胃癌E cad异常表达率 (82 .8% )显著高于胃腺瘤 (5 0 .0 % ) ,E cad的表达异常与胃癌的分化程度、淋巴结转移、浸润深度和肿瘤大小密切相关。胃癌 β cat的异常表达率 (79.3% )高于胃腺瘤(6 0 .0 % ) ,β cat的表达异常与胃癌的分化程度、淋巴结转移密切相关 ,与胃癌的浸润深度、肿瘤大小无相关性。结论　E cad和 β cat的异常表达与胃癌的分化和转移密切相关 ,检测E cad和 β cat的表达可作为判断胃癌侵袭、转移的良好参考指标。Objective To study the expression and clinical significance of E-cadherin and β-catenin in gastric carcinoma.Methods Specimens from gastric carcinoma (58 cases),gastric adenoma (20 cases) and normal gastric tissues (18 cases) for which tissue microarrays were constructed and used for immunohistochemical detection of E-cadherin and β-catenin protein expression.Results Immunohistochemical analysis of tissue microarrays demonstrated E-cadherin protein expression in 82.8% of the gastric carcinoma and only in 50.0% of gastric adenoma.E-cadherin expression was significantly correlated with tumor differentiation status,lymph node metastasis,depth and size of tumors.β-catenin expression was associated with tumor differentiation status and lymph node metastasis.While in tumors depth and size,there was no significance.Conclusion E-cadherin and β-catenin expression are associated with invasion and metastasis of gastric carcinoma,and are important factors for judging invasion of gastric carcinoma.

关 键 词：胃癌 E钙粘素 Β-连环素 组织芯片 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]