2-甲基-1,2,5,6-四氢-5,6-二氧-1,2,4-三嗪-3-硫醇的合成研究  

Study on synthesis of 2-methyl-1,2,5,6-tetrahydro-5,6-dioxo-1,2,4-triazine-3-thiol

作　　者：侯永 刘景俊 石其德 

机构地区：[1]鲁南制药股份有限公司,临沂276005

出　　处：《齐鲁药事》2004年第8期42-43,共2页qilu pharmaceutical affairs

摘　　要：目的　制备 2 -甲基 - 1,2,5,6 -四氢 - 5,6 -二氧 - 1,2,4 -三嗪 - 3-硫醇。方法　在甲醇的碱性介质中,通过1-甲基 - 1-氨基硫脲与草酸二乙酯的缩合反应制备医药中间体三嗪环。结果及结论　适宜的反应条件为 1-甲基 - 1-氨基硫脲、草酸二乙酯、甲醇钠的量(摩尔)比例为 1 0∶1 1∶2 0,其收率可达 6 0 %。Objective To study the synthesis of 2-methyl-1,2,5,6-tetrahydro-5,6-dioxo-1,2,4-triazine-3-thiol.Methods Triazine was made by condensing 1-methyl-1-thiosemicarbazide with oxalic diacetate in alkalified methanol.Results and conclusions The proportion of 1-methyl-1-thiosemicarbazide,oxalic diacetate and sodium methoxide was 1.0∶1.1∶2.0,and the yield was 60% under the suitable reaction condition.

关 键 词：甲基 草酸二乙酯 合成研究 三嗪环 甲醇钠 硫醇 收率 适宜 制备 目的 

分 类 号：R914[医药卫生—药物化学] TQ225[医药卫生—药学]