多肽类药物的口服吸收及其剂型研究  

The Study of Oral Absorption and Delivery Systems for Peptide Drugs

作　　者：张洁[1] 张纯[1] 高申[2] 

机构地区：[1]第二军医大学长征医院药学部,上海200003 [2]第二军医大学药学院药剂学教研室,上海200433

出　　处：《药学进展》2004年第10期437-441,共5页Progress in Pharmaceutical Sciences

摘　　要：根据国外有关文献 ,分析了多肽类药物口服生物利用度低的原因 ,包括胃肠道黏膜的低渗透性、胃酸和各种消化酶的降解作用及首过效应等 ,并介绍从结构修饰、处方和剂型设计三方面提高多肽口服生物利用度的方法。Oral delivery systems for peptide drugs have been the focus of intense research in recent years, although it is widely recognized that numerous limitations apply to the oral bioavailability of peptides, such as poor membrane permeability, degradation by gastrointestinal juice, hepatic metablism and so on. Methods to overcome these limitations were reviewed in this paper, including structure modification, prescription and dosage form design.

关 键 词：口服 多肽类药物 剂型 生物利用度 胃肠道黏膜 胃酸 处方 消化酶 降解作用 吸收 

分 类 号：TQ464[化学工程—制药化工]