氧自由基对口腔粘膜损伤的动物实验研究(Ⅳ)——粘膜组织中生化指标的研究和综合分析  

A Research on the Damage of Oxygen Free Radicals to the Oral Mucosa of Animal(Ⅳ)—Biochemical Observations

作　　者：陈谦明[1] 李秉琦[1] 萧卓然 郑光静[2] 易平[2] 东云华[3] 

机构地区：[1]华西医科大学口腔医学院 [2]华西医科大学口腔医学研究所 [3]华西医科大学公共卫生学院

出　　处：《华西口腔医学杂志》1993年第2期138-141,共4页West China Journal of Stomatology

基　　金：国家教委基金资助课题 编号C19005

摘　　要：为了解甲基紫精诱导的氧自由基造成口腔粘膜急性非特异性坏死性炎症的机制,对动物口腔粘膜组织进行了生化指标测定及综合分析,结果发现:随着氧自由基的产生,超氧化物岐化酶活性下降,并与氧自由基间呈指数曲线关系变化;氨基已糖升高,标志着粘膜固有层蛋白多糖分解增多。In order to partly understand the mechanisms of morphological changes caused by oxygen free radicals(OFR) induced by paraquat(PQ),12 different enzymes were detected and observed by enzyme histological methods.Among them,6 locate on mitochondria,2 in cytoplasm,1 on lysosomes,and 3 on membrane structures individually.The results showed that the generation of OFR induced by PQ first came from the oxidation of NADPHD in cellu-lar structures.With the depletion of NADPH and increasing of OFR,the activity of these enzymes in cellular struc-tures decreased.The results indicated that these processes involved with the formation of inflammation and ulcerson the oral mucosa of hamster cheek pouch.

关 键 词：氧自由基 口腔粘膜疾病 生物化学 

分 类 号：R781.503[医药卫生—口腔医学]