急性根尖周炎患牙根管内厌氧菌的细菌学研究——第3报 患牙根管内厌氧菌诱生白细胞介素—1的研究  

Bacteriological Study on Anaerobic Bacteria Isolated from Infected Root Canals of Teeth with Acute Periapical Lesions Section 3:The Studies on the Induction of Interleukin-1 Production of the Anaerobic Bacteria

作　　者：赵雪梅[1] 邓惠姝[1] 章崇杰[2] 袁必文[2] 

机构地区：[1]华西医科大学口腔医学院 [2]华西医科大学基础医学院

出　　处：《华西口腔医学杂志》1993年第3期217-219,共3页West China Journal of Stomatology

基　　金：国家教委博士点专项基金

摘　　要：本研究以细菌内毒素脂多糖(LPS)为阳性对照,采用淋巴细胞激活因子分析法对25株急性根尖周炎患牙根管内厌氧菌诱生白细胞介素—1的能力进行了研究。结果显示超声粉碎菌体以及菌培养上清液均具有较强的白细胞介素—1诱生力。G^-菌的诱生力主要来自菌体成分,以颊类杆菌和牙龈类杆菌最强;G^+菌的诱生力主要来自其代谢产物,以短真细菌和痤疮丙酸杆菌最强。表明感染根管内厌氧菌很可能通过白细胞介素—1而介导急性根尖周病变的发生。In the present study,the induction effects of 25 anaerobic bacteria strains isolated from infected root canals of teeth with acute periapical lesions on Interleukin-1 production were determined with the LAF method.LPS servedas a positive control.The results showed that both G^+ and G^- anaerobes had high induction effects on IL-1 pro-duction by their sonic extracts and culture supernatants.It was suggested that the anaerobic bacteria possibly in-duced the acute periapical lesions through IL-1's immune and infective mediation.

关 键 词：根尖周炎 厌氧菌 白细胞介素 根管 

分 类 号：R781.341[医药卫生—口腔医学]