双炔失碳酯类似物的抗早孕构效关系  

QSAR OF ANTI-EARLY PREGNANCY WITH ANORDRIN ANALOGS

作　　者：周群[1] 李正化[1] 钟裕国[1] 李瑞雪[1] 

机构地区：[1]华西医科大学药学院

出　　处：《华西药学杂志》1993年第2期67-69,共3页West China Journal of Pharmaceutical Sciences

摘　　要：本文对17个双快失碳酯类似物的抗早孕活性与酯侧链的结构因素进行逐步回归分析,得到双炔失碳酯类似物抗早孕活性的构效关系方程。对其合理性及预见性进行了检验。方程表明双炔失碳酯的抗早孕活性与侧链脂水分布系数和立体效应有关。QSAR f anti-earlypregnancy with seventeen Anordrin an-alogs was established with stepwise reg-rossion analysis. Its rationality and pre-dictability were identified. QSAR sh-own that the anti-early pregnant effectof Anordrin analogs is related to Parti-tion coefficient and Stereo effect.

关 键 词：双炔失碳酯 类似物 抗早孕 

分 类 号：R962[医药卫生—药理学]