噬菌体肽库技术的应用  

The applications of phage peptide library techniques

作　　者：王宪文[1] 毕英佐[1] 曹永长[1] 于康震 

机构地区：[1]华南农业大学动物科学院基因工程室,广州510642 [2]哈尔滨兽医研究所,哈尔滨150001

出　　处：《生物技术通讯》2004年第5期489-491,共3页Letters in Biotechnology

摘　　要：噬菌体肽库是由大量带有不同肽段的单个噬菌体组成的重组噬菌体库,通过分析筛选到的多肽的结构和序列,可以了解蛋白质分子之间的相互作用。随着生物技术的发展,噬菌体肽库技术在基因治疗、抗原表位定位、确定核酸结合蛋白、基因疫苗研究和药物筛选等方面得到广泛应用并取得了很大进展。Phage peptide libraries are collections of the specific length of short peptides, and they are based on phages as their carriers. Through the structure and sequence analyzing of the selected peptides, we can have some knowledge of the interactions between proteins with the development of biological technology. Phage peptide libraries have been made much progress in many aspects and are widely used in many fields, such as genetic treatment, defining antigen momitopes and nucleic acid-binding proteins, the study of genetic vaccine and selection of medicines.

关 键 词：噬菌体肽库 药物筛选 抗原表位 基因治疗 结合蛋白 基因疫苗 多肽 蛋白质分子 核酸 序列 

分 类 号：Q51[生物学—生物化学] R392[医药卫生—免疫学]