PMBP缩氨基酚配合物的合成、结构和抑菌活性  

Synthesis, Structure and Antibacterial Activities of Complexes Derived from PMBP and Aminophenol

作　　者：张姝明[1,2] 倪丽琴[3] 贾永金[4] 王瑾玲[4] 

机构地区：[1]河北工业大学化工学院 [2]天津师范大学化学与生命科学院,天津300074 [3]天津科技大学 [4]天津师范大学化学与生命科学院

出　　处：《Chinese Journal of Structural Chemistry》2004年第7期793-797,共5页结构化学（英文）

摘　　要：利用PMBP缩邻、间和对氨基酚配体(C23H19N3O2), 合成了它们的Cu (II), Co (II), Fe (II) 和Zn (II) 配合物. IR, UV, 1 H NMR和EI-MS测定结果表明PMBP缩邻氨基酚配体以负二价三齿形式与金属形成1:1的配合物, 而PMBP缩间氨基酚和PMBP缩对氨基酚配体均以二齿形式与金属形成2:1的配合物。抑菌活性测定结果表明配合物对金黄色葡萄球菌和大肠杆菌的抑制活性大于配体, 其中PMBP缩邻氨基酚合钴(II) 配合物在2.5 g/L浓度下对大肠杆菌的抑菌环直径达到19 mm, 为研究配合物的生物活性提供了科学依据。Using the ligand derived from 1-phenyl-3-methyl-4-benzoyl-pyrazolin-5-one (PMBP) and o-, m- and p-aminophenol (C23H19N3O2), their Cu(II), Co(II), Fe(II) and Zn(II) complexes were synthesized and characterized by IR, UV, H-1 NMR and EI-MS, indicating that the PMBP-o-aminophenol as a -2 valence tridentate and m- and p-aminophenol as -1 valence bidentates with metals form 1:1 and 2:1 complexes, respectively. The tests of antibacterial activities suggest that the complexes have better antibacterial activities against E. cocli and S. aureus than the ligand, in which the diameter of the antibacterial ring is 19 mm against E. cocli for the Co(II) complexes derived from PMBP and o-aminophenol at 2.5 g/L chrome. It provides a scientific basis for studying the biological activities of the complexes.

关 键 词：PMBP缩氨基酚 配合物 合成 晶体结构 抑菌活性 席夫碱 

分 类 号：O641.4[理学—物理化学]