瘦素、脂肪酸对大鼠胰岛细胞解偶联蛋白2mRNA表达的影响  

Effect of leptin and fatty acids on uncoupling protein-2 mRNA in rat islet cells

作　　者：强桂芬[1] 冯凭[1] 崔景秋[1] 郑宝忠[1] 赵洪林[1] 李颖利[1] 

机构地区：[1]天津医科大学总医院内分泌科,300052

出　　处：《中华内分泌代谢杂志》2004年第4期367-368,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：天津市自然科学基金资助项目(023616811)

摘　　要：以瘦素、脂肪酸作用于体外培养的大鼠胰岛细胞,以甘油三酯含量,解偶联蛋白2mRNA表达水平为指标,显示瘦素通过外周途径调节产热,脂肪酸可损害胰岛功能。After rat pancreatic islets were isolated and cultured with leptin and fatty acids, intracellular triglyceride content and uncoupling protein-2 mRNA expression were measured. The results show that leptin can regulate thermogenesis by peripheral path-way and fatty acids may impair the function of islets.

关 键 词：瘦素 mRNA表达 胰岛细胞 大鼠 解偶联蛋白2 脂肪酸 外周 产热 体外培养 水平 

分 类 号：R363[医药卫生—病理学]