肠易激综合征中西医结合治疗前后肠道菌群状况观察  

Observation on intestinal flora in patients of irritable bowel syndrome after treatment of Chinese integrative medicine

作　　者：孙旭[1] 蔡淦[2] 王文健[3] 

机构地区：[1]复旦大学附属华山医院消化科,上海200040 [2]上海中医药大学附属曙光医院内科,上海200021 [3]复旦大学附属华山医院中医科,上海200040

出　　处：《中西医结合学报》2004年第5期340-342,共3页Journal of Chinese Integrative Medicine

摘　　要：目的:观察中西医结合治疗腹泻型肠易激综合征(irritablebowelsyndrome,IBS)的临床疗效,了解患者肠道菌群调节状况。方法:选择60例患者,按照罗马Ⅱ诊断标准均为腹泻主导型IBS,中医辨证多属脾虚肝乘型。随机分为2组,各30例。中西医结合组采用痛泻要方加米雅BM;西药组服用米雅BM。连服4周为1个疗程。观察治疗前后l临床症状,大便培养检测治疗前后大肠杆菌群、肠球菌群、乳酸菌群、双歧杆菌群。结果:中西医结合组症状缓解优于西药组(P<0.05),治疗后肠道菌群中双歧杆菌、乳酸菌量上升,而具有潜在致病性的大肠杆菌和肠球菌有一定的下降,其调节改善作用优于单用西药组(P<0.05)。结论:联合用药能较好改善症状,较好调节肠道菌群,恢复平衡状态。Objective:To observe the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating irritable bowel syndrome (IBS) and the result of intestinal flora regulation. Methods: Sixty IBS patients, 36 males and 24 females, were divided into two groups, with 30 patients in each group. Herbal formula of TongxieYaofang and clostridi-um butyricum (Cb) were used in the first group for four weeks, while only Cb was used for four weeks in the second group. We observed the changes of coliform group, enterococcus, lactobacillus, bifidobacterium after treatment. Results:The effective rate of the Tongxie Yaofang and Cb treated group was significantly higher than that of the Cb treated group ( P <0. 05). The numbers of bifidobacterium and lactobacillus increased, while the numbers of coliform group and enterococcus decreased after the treatment, and the changes of intestinal flora in the integrative medicine treated group were significantly greater than those in the Cb treated group. Conclusion: After treatment with the combination of traditional Chinese medicine and western medicine, the intestinal flora can be regulated to equilibrium state.

关 键 词：肠道菌群 药组 观察 西药 治疗前后 米雅BM 中西医结合治疗 单用 目的 结论 

分 类 号：R574[医药卫生—消化系统] R289[医药卫生—内科学]