过氧钒烟酸对糖尿病鼠苯丙氨酸羟化酶活性的影响  

Effect of peroxovanadate nicotinic acid on phenylalanine hydroxylase activity in diabetic rats

作　　者：王艳林[1] 余斌杰[1] 黎宗保[1] 何哲明[2] 胡少眉[2] 

机构地区：[1]中山医科大学附属第一医院内分泌研究室,510080 [2]中山医科大学附属第一医院,510080

出　　处：《中华内分泌代谢杂志》1998年第2期123-125,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：广东省自然科学基金;博士后科研基金

摘　　要：目的　探讨过氧钒烟酸（ Ｐ Ｏ Ｖ） 的降血糖作用的分子生物学机制。方法　选用 Ｓ Ｄ 大鼠用链脲佐菌素诱导产生糖尿病鼠动物模型，观察用 Ｐ Ｏ Ｖ 和美迪康（ Ｍｅｔ） 治疗后各组大鼠血、尿糖水平及血肝细胞质中苯丙氨酸羟化酶（ Ｐ Ａ Ｈ） 活性改变情况，并进行比较。结果　糖尿病鼠 Ｐ Ａ Ｈ 活性明显增高，用 Ｐ Ｏ Ｖ治疗４ 周后活性受到抑制，血糖水平明显下降，临床症状得以改善。结论　 Ｐ Ｏ Ｖ 的降糖作用优于美迪康，且未见明显毒副作用。Objective To investigate into the molecular biological mechanism of hypoglycemic effect ofperoxovanadate nicotinic acid ( P O V) on diabetic rats . Methods The streptozotocin induced diabetic S Drats wereselected as the animal model. The blood and urine glucose levels as well as liver plasma phenylalanine hydroxylase( P A H) activity were observed in all groups of rats after P O Vand metformin treatment . Results P A Hactivity inthe diabetic rats was obviously increased . After P O V treatment for 4 weeks , P A H activity was inhibited , bloodglucose levelis decreased markedly and the clinical sym ptoms were im proved . Conclusion The P O V had bettereffectthan m etformin in decreasing hyperglycemia and side effects had not been observed .

关 键 词：糖尿病 苯丙氨酸羟化酶 POV 治疗后 酶活性 PAH 降糖作用 分子生物学机制 肝细胞 胞质 

分 类 号：R587[医药卫生—内分泌] R155.5[医药卫生—内科学]