氟西汀与舍曲林治疗强迫症的比较研究  

A comparative study of fluoxetine and sertraline in the treatment of obsessive-compulsive disorder

作　　者：刘玉厚[1] 姚传斌[1] 徐敏秀[1] 郑振宝[1] 

机构地区：[1]山东省临沂市精神卫生中心,276005

出　　处：《山东精神医学》2004年第4期204-206,共3页Shangdong Archives of Psychiatry

摘　　要：目的　比较氟西汀与舍曲林对强迫症的临床疗效及副反应。方法　将 5 8例强迫症患者随机分为两组 ,分别应用氟西汀和舍曲林治疗 ,疗程均为 10周 ,采用Yale Brown强迫量表 (Y BOCS)、汉密尔顿抑郁量表 (HAMD)、汉密尔顿焦虑量表 (HAMA)、副反应量表 (TESS)和临床疗效评定标准 ,分别评定临床疗效和副反应。结果　氟西汀组与舍曲林组疗效近似 ,氟西汀组显效率为 6 0 .71% ,有效率为 89.2 9% ,两组的显效率和有效率差异无显著性 (P >0 .0 5 ) ,且起效时间相近 ;各组治疗前、后Y BOCS、HAMD、HAMA总分比较差异有极显著性 (P <0 .0 1)。氟西汀组与舍曲林组副反应发生率差异无显著性 (P >0 .0 5 )。结论　氟西汀与舍曲林对强迫症均有较好的疗效 ,起效较快 ,副反应少 。Objective The purpose of this study was to investigate the clinical efficacy and the side effects of fluoxetine and sertraline in the treatment of obsessive-compulsive disorder (OCD).Methods A total of 58 patients who met the CCMD-3 criteria for OCD were randomly assigned to two groups.One group was treated with fluoxetine and the other with sertraline for 10 weeks.The efficacy was measured with Yale-Brown Obsessive Compulsive Scale (Y-BOCS),Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA).The side effects were assessed by Treatment Emergent Symptoms Scale (TESS).Results The significant improvement rate of fluoxetine was 60.71% and the improvement rate was 89.29%,but there were no significant differences between the two groups.The reducing scores of Y-BOCS,HAMD and HAMA were no significant differences between the two grups.The side effects of fluoxetine was similar to sertraline.Conclusion Fluoxetine is an effective antidepressant with few side effects and takes into effect rapidly.

关 键 词：舍曲林 氟西汀 治疗 副反应 强迫症 HAMA HAMD 显著性 结论 差异 

分 类 号：R749[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]