柞蚕蛹虫草对老龄大鼠单胺氧化酶活性和脂褐质及羟脯氨酸含量的影响  

Effects of Cordyceps militaris(L) Linr on monoamine oxidase activity and contents of lipofuscin and hydroxyproline in senile rats

作　　者：张桂英[1] 王宝贵[1] 赵林伊[1] 刘娅[1] 周燕[2] 

机构地区：[1]吉林大学公共卫生学院营养与食品卫生学教研室,吉林长春130021 [2]吉林省职业病防治院,吉林长春130061

出　　处：《吉林大学学报（医学版）》2004年第5期730-732,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省农业厅资助课题 (2 0 0 0 30 3- 11.2 ) ;国家专利 (ZL8710 6 987.3)

摘　　要：目的 :探讨柞蚕蛹虫草对老龄 Wistar雄性大鼠组织中的单胺氧化酶 (MAO- B)活性、脂褐质及羟脯氨酸含量的影响。方法 :经口给药 14 d后 ,采用紫外比色法测定 MAO- B活性 ,用荧光比色法测定脂褐质含量及分光光度法测定羟脯氨酸含量。结果 :3个老龄实验组的 MAO- B活性、脂褐质及羟脯氨酸含量与老龄对照组比较 ,差异均有显著性 (P<0 .0 5 )。结论 :柞蚕蛹虫草具有降低老龄实验组脑、肝组织中 MAO- B活性 ,降低心、肝、脑组织中羟脯氨酸含量的作用 ,且能增加皮肤中羟脯氨酸的含量。Objective To observe the effects of Cordyceps militaris(L) Linr (CML) on monoamine oxidase (MAO-B) activity, and contents of lipofuscin and hydroxyoroline in senile Wistar rats. Methods The activity of MAO-B was detected by ultraviolet-spectrophotometry, the content of lipofuscin was measured by spectrofluorimetry, and the content of hydroxyproline was tested by spectrophotometry 14 days after administration of CML. Results The MAO-B activity, the contents of lipofuscin and hudroxyproline in tissues were significantly different in experimental groups compared with control (P<0.05). Conclusion CML can reduce the MAO-B activity in brain and liver, and decrease the lipofuscin content in heart, liver, and brain. It also can increase hydroxyproline content in skin.

关 键 词：柞蚕蛹虫草 单胺氧化酶 代谢 脂褐质 代谢 羟脯氨酸 代谢 大鼠 

分 类 号：R-332[医药卫生] R285.5