低碘对大鼠胸腺细胞角蛋白18阳性上皮细胞的影响  

Effect of low-iodine diet on cytokeratin-18 positive thymic epithelial cells in rats

作　　者：刘皓[1] 张国权[1] 李金茹[1] 王俊艳[1] 王世忠[1] 刘金宝[2] 阎玉芹[2] 陈祖培[1] 

机构地区：[1]天津医科大学组织胚胎学教研室,天津300070 [2]天津市内分泌研究所

出　　处：《解剖学研究》2004年第3期191-194,i004,共5页Anatomy Research

基　　金：国家自然科学基金重点资助项目 (3 0 2 3 0 3 3 0 ) ;天津医科大学科研资助项目 (2 0 0 1KY3 4)

摘　　要：目的　探讨甲状腺功能降低时大鼠胸腺上皮细胞的变化。方法　将断乳后 1个月的 30只Wistar大鼠随机分为2组 :正常组饲以正常饲料 ,饮用自来水 ;低碘组饲以低碘饲料 ,饮用去离子水。测定各组大鼠的尿碘、血清甲状腺激素、胸腺指数及胸腺CK18阳性上皮细胞体密度和数密度的变化。结果　低碘组大鼠的尿碘、血清甲状腺激素及胸腺指数显著降低 ;实验 6个月后 ,CK18阳性上皮细胞的体密度和数密度显著升高。结论　低碘可促进大鼠胸腺CK18阳性上皮细胞增生。Objective To study the changes of thymic epithelial cells in condition of thyroid hormone deficiency. Methods Thirty Wistar rats, 1 month after stopping laction, were divided into 2 groups randomly. Normal group was fed with normal-iodine food and drink tap water. Low iodine group was fed with low-iodine food and drink deion water. Three months later, we measure iodine in urine, thyroid hormone in serum, thymic index and volume density(Vv)and numerical density on area(NA)of CK18 positive thymic epithelial cells. Results Iodine in urine, thyroid hormone in serum and thymic index decreased drastically in low iodine group. However, volume density(Vv)and numerical density on area(NA)of CK18 positive thymic epithelial cell increased. Conclusions CK18 positive thymic epithelial cells can be proliferated in condition of iodine deficiency.

关 键 词：低碘 Wistar大鼠 阳性 胸腺上皮细胞 血清甲状腺激素 角蛋白1 尿碘 鼠胸腺细胞 变化 

分 类 号：R361[医药卫生—病理学]