鼻腔非霍奇金淋巴瘤75例预后分析  

Prognostic Analysis of 75 Cases with Primary Nasal Non-Hodgkins Lymphoma

作　　者：双跃荣[1] 黎虹[1] 李国庆[1] 黄晖[1] 樊光华[1] 万莉娟[1] 吴耀华[1] 陈建祥[1] 叶大茜[1] 

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2004年第4期398-400,共3页The Practical Journal of Cancer

摘　　要：目的　分析鼻腔非霍奇金淋巴瘤的临床特征和预后因素。方法　回顾性分析 1988年 6月至 2 0 0 2年 3月收治的 75例鼻腔非霍奇金淋巴瘤临床资料。临床分期按AnnArbor分期及肿瘤局部侵犯范围分区标准。预后判断采用Cox多因素回归模型分析。结果　 75例 5年生存率为 5 0 .7% ( 3 8/ 75 )。影响预后的主要因素 :①病理类型 ,鼻型NK /T细胞淋巴瘤患者生存期均未超过 3年 ,1年、2年生存率分别为 61.5 % ( 8/ 13 )和 3 0 .7% ( 4 / 13 ) ,预后极差。②临床分期 ,Ⅰ、Ⅱ、Ⅲ和Ⅳ期 5年生存率分别为71.4% ( 2 0 / 2 8)、5 4.5 % ( 12 / 2 2 )、42 .9% ( 6/ 14 )和 0 ( 0 / 11) (P <0 .0 1)。③肿瘤局部侵犯范围 ,T1区、T 2区、T 3区患者 5年生存率分别为 74.1% ( 2 0 / 2 7)、45 .2 % ( 14 / 3 1)和 2 3 .5 % ( 4 / 17) (P <0 .0 1) ,肿瘤局部侵犯范围对预后有显著影响。④治疗方法 ,放化疗综合治疗、单纯放疗和单纯化疗者 5年生存率分别为 68.4% ( 2 6/ 3 8)、44 .1% ( 12 / 2 7)和 0 ( 0 / 10 ) (P <0 .0 5 )。结论　病理类型、临床分期及肿瘤局部侵犯范围是影响鼻腔非霍奇金淋巴瘤的主要预后因素 ,应采用放疗。Objective To investigate the clinical characteristics and prognostic factors of primary nasal non-Hodgkins Lymphoma(NHL).Methods Data of 75 cases with primary nasal non-Hodgkins Lymphoma who were admitted between June,1988 and March,2002 in our hospital were retrospectviely analyzed.The tumor was assessed by the Ann Arbor staging system and the extension of primary tomor.Results The overrall 5-year survival rate was 50.7%(20/28).The prognostic factors were analyzed by Cox regression model:①patients with primary nasal NK/T cell Lymphoma had very poor prognosis.The 1-year and 2-year survival rate were 61.5%(8/13) and 30.7%(4/13),respectively.②The 5-year survival rate was 71.4%(20/28) for stage Ⅰ disease,54.5%(12/22) for stage Ⅱ disease,42.9%(11/14) for stage Ⅲ disease and 0 for stage Ⅳ disease(P<0.01).③The extention of primary tumour had a significant relation with survival.The 5-year survival rate were 74.1%(20/27),45.2%(14/31) and 23.5%(4/17) respectively for T1,T2,and T3 disease(P<0.01).④The combined radiochemotherapy increased survival rate markedly(P<0.05).Conclusion The prognostic factors of primary nasal NHL include the pathological type,the stage and the extention of primary tumour.Combined radiochemotherapy can achieve better result.

关 键 词：肿瘤 鼻腔非霍奇金淋巴瘤 生存率 侵犯范围 局部 临床分期 预后 结论 主要因素 方法 

分 类 号：R739[医药卫生—肿瘤] R735[医药卫生—临床医学]