盐酸格拉司琼预防肝癌介入化疗栓塞术后患者恶心呕吐的疗效观察  

Effect of Granisetron on Vomitting Caused by Transarterial Chemoembolization(TACE)

作　　者：朱晓锋[1] 李国安[2] 

机构地区：[1]江苏省常熟市第一人民医院,215500 [2]上海复旦大学附属肿瘤医院,200032

出　　处：《实用癌症杂志》2004年第4期411-412,共2页The Practical Journal of Cancer

摘　　要：目的　探讨盐酸格拉司琼对于预防肝介入化疗栓塞术后引起的患者恶心、呕吐的疗效。方法　将 64例肝介入化疗栓塞患者随机分为格拉司琼治疗组 ( 3 2例 )和胃复安 +安定对照组 ( 3 2例 )。格拉司琼组 ,即在介入术中未灌注治疗药物前 ,通过导管向动脉内注射盐酸格拉司琼 3mg。胃复安 +安定组 ,即在介入术前 3 0min肌注胃复安 2 0mg和安定 10mg。观察 2组术后 3天内患者的恶心、呕吐等不良反应。结果　格拉司琼组与胃复安 +安定组止吐疗效比较有显著性差异 (P <0 .0 5 ) ;其他不良反应观察 ,治疗组发生次数明显少于对照组。结论　盐酸格拉司琼对肝介入化疗栓塞术患者是有效的止吐药物 。Objective To evaluate the prophylactic efficacy of granisetron on vomiting caused by TACE.Methods 64 Patients were randomly divided into two groups to receive either granisetron via liver artery injection(n=32) or metoclopramidum combined with diazepam as controls(n=32).The antiemetic efficacy were compared between the two groups during the three days after TACE.Results The effective rate of granisetron group was significantly higher than that of the control group(P<0.05).Conclusion Granisetron is an effective antiemetic drug in controlling vomiting caused by TACE and should be advocated in clinical practice.

关 键 词：患者 盐酸格拉司琼 介入化疗栓塞 胃复安 安定 术后 恶心呕吐 结论 显著性差异 目的 

分 类 号：R735[医药卫生—肿瘤] R730[医药卫生—临床医学]