老年脑梗死患者血浆神经肽Y、降钙素基因相关肽水平的动态变化  

Dynamic changes of levels of neuropeptide Y and calcitonin gene-related peptide in plasma of elderly patients with cerebral infarction

作　　者：李义召[1] 曹秀玲[2] 宋成忠[1] 朱士文[1] 谢遵伟[1] 孙琳[3] 张东君[4] 刘爱芬[4] 刘建伟[5] 孙若鹏[6] 

机构地区：[1]济南长城医院神经内科,山东省济南市250100 [2]山东医科大学齐鲁医院科研处,山东省济南市250012 [3]山东大学附属第二医院神经内科,山东省济南市250100 [4]山东医科大学齐鲁医院神经内科,山东省济南市250012 [5]山东医科大学齐鲁医院同位素科,山东省济南市250012 [6]山东医科大学齐鲁医院儿科,山东省济南市250012

出　　处：《中国临床康复》2004年第31期6939-6941,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察老年脑梗死患者神经肽Y、降钙素基因相关肽(calcitoningene-relatedpeptide,CGRP)水平改变及其动态变化,探讨神经肽Y、CGRP参与老年脑梗死的病理生理机制及其临床意义。方法:选择老年脑梗死患者42例,依病情轻重分为轻型12例,中型18例,重型12例。依病灶大小分为大灶组22例,小灶组20例。按病程分为≤24h组19例,1～3d组22例、4～7d组27例、8～15d组21例及>15d组18例。按伴发病积分分为<6分组25例与≥6分组17例。按有无高血压史分为有高血压史组18例与无高血压史组24例。选择30例健康老人查体者作为对照组。用放免法检测血浆神经肽Y与CGRP浓度。结果:神经肽Y的变化:老年脑梗死组神经肽Y水平犤(590.66±305.45)ng/L犦显著高于对照组犤(114.76±65.92)ng/L犦(t=5.2846,P<0.0001),于发病后24h内犤(439.13±237.80)ng/L犦显著升高,1～3d犤(668.54±261.44)ng/L犦达高峰,8～15d犤(528.59±215.67)ng/L犦开始下降,15d犤(372.80±200.96)ng/L犦后仍在较高水平;重型犤(698.96±206.85)ng/L犦与大灶组犤(769.61±296.48)ng/L犦显著高于轻型犤(488.60±201.75)ng/L犦与小灶组犤(483.40±312.31)ng/L犦(P<0.01),发病积分≥6分组犤(631.28±286.86)ng/L犦显著高于<6分组犤(573.35±337.64)ng/L犦(t=2.9687,P<0.AIM: To observe the changes and dynamic changes of plasma levels of neuropeptide Y and calcitonin gene-related peptide(CGTP) in elderly patients with cerebral infarction(CI), and investigate the pathophysiological mechanism and clinical significance of neuropeptide Y and CGRP in elderly CI. METHODS: Forty-two elderly CI patients were involved in the study. They were divided into mild CI group(n=12), moderate CI group(n=18) and severe CI group(n=12) according to their severities of CI; into large focal size group(n=22) and small focal size group(n=20) according to their focal size; into ≤24 hours group(n=19), 1 to 3 days group(n=22), 4 to 7 days group (n=27), 8 to 15 days group(n=21) and >15 days group(n=18) according to their disease course; into < 6 group(n=25) and ≥6 group(n=17) according to their episode score; into hypertension history group(n=18) and non-hypertension group(n=24) according to whether they had the history of hypertension or not. Another 30 healthy elderly subjects were taken as the controls. The plasma levels of neuropeptide Y and CGRP were measured by radioimmunoassay. RESULTS: The plasma level of neuropeptide Y in the elderly CI group [(590.66±305.45) ng/L]was significantly higher than that in the control group [(114.76±65.92) ng/L] (t=5.284 6, P< 0.000 1).It started to increase significantly during the 24 hours [(439.13±237.80) ng/L], and reached the peak value at 1 to 3 days [(668.54±261.44) ng/L], and it began to decrease at 8 to 15 days [(528.59±215.67)] ng/L, and was still higher after 15 days [(372.80±200.96) ng/L]. The plasma levels of neuropeptide Y in the severe CI group[(698.96±206.85) ng/L ]and large focal size group [(769.61±296.48) ng/L] were significantly higher than those in the mild CI group [(488.60±201.75) ng/L] and small focal size group[(483.40±312.31) ng/L](P< 0.01); It was higher in the≥6 scores groups[(631.28±286.86) ng/L] than in the < 6 scores group [(573.35±337.64) ng/L](t=2.968 7, P< 0.01), higher in the hypertension group [(697.37±310.33) ng/

关 键 词：老年脑梗死 CGRP 血浆神经肽Y 患者 对照组 降钙素基因相关肽 发病 高水平 参与 结论 

分 类 号：R743[医药卫生—神经病学与精神病学] R277.733.3[医药卫生—临床医学]