CDK_2在金黄地鼠颊囊癌变过程中的表达的研究  

Study of Expression of CDK_2 in Hamster Buckle Pouch Carcinogenesis

作　　者：孙淑芬[1] 高文信[1] 刘岩[2] 刘敏[1] 李晓丽[1] 刘树泰[1] 

机构地区：[1]吉林大学口腔医学院口腔内科,吉林长春130041 [2]吉林大学第四医院口腔科

出　　处：《口腔医学研究》2004年第5期480-482,共3页Journal of Oral Science Research

摘　　要：目的 :探讨CDK2 在金黄地鼠颊囊黏膜从正常黏膜到单纯增生、异常增生及鳞癌的表达变化。方法 :采用DMBA诱导 4 8只金黄地鼠颊囊癌变动物模型 ,SABC免疫组化法检测CDK2 蛋白的表达。结果 :CDK2 在异常增生上皮及鳞癌的表达与正常和单纯增生组相比明显提高 (P <0 .0 5 ) ,阳性染色等级随病理等级改变提高 (P <0 .0 5 )。结论 :CDK2 参与了口腔黏膜癌前病变和鳞癌的发生与发展。Objective: To study the expression of CDK 2 in hamster buckle pouch normal mucosa、hyperplasia、dysplasia and squamous cell carcinoma. Method: SABC immunohistochemical assay was used to measure the level of CDK 2 in DMBA induced 48 hamsters buckle pouch carcinogenesis model. Result: The expression of CDK 2 in dysplasia and carcinoma were apparently higher compared with normal and hyperplasiaIn(P< 0.01), the positive staining grade was correlated with the pathologic grades(P<0.01). Conclusion: CDK 2 may take part in malignant transformation of oral benign lesions.

关 键 词：金黄地鼠 口腔黏膜癌前损害 口腔鳞状细胞癌 CDK2 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]