血管内皮生长因子水平在诊断食管癌和胃癌中的临床价值  

Clinical value of serum vascular endothelial growth factor in diagnosis of esophageal neoplasm and stomach neoplasm

作　　者：康鲁东[1] 吴伟芳[1] 马宪军[2] 胡晓燕[1] 于清水[1] 姜安丽[1] 

机构地区：[1]山东大学医学院生化与分子生物学研究所,山东济南250012 [2]山东大学齐鲁医院血库,山东济南250012

出　　处：《山东大学学报（医学版）》2004年第5期522-524,共3页Journal of Shandong University:Health Sciences

基　　金：山东省卫生厅立项课题(2001CA1CAB14)。

摘　　要：目的:探讨人血清血管内皮生长因子穴VEGF雪诊断食道肿瘤和胃肿瘤的临床价值。方法:采用酶联免疫检测法(ELISA)定量检测37例食管癌、31例胃癌及15例正常对照者血清中VEGF的含量。结果:两种恶性肿瘤患者血清VEGF水平均显著高于正常对照组(P<0.01)并与临床病理特征,如浸润深度、淋巴结转移、TNM分期等密切相关。结论:血清VEGF水平在食管癌、胃癌的浸润和转移中起重要作用熏可作为食管癌、胃癌进展和评估预后的血清学指标。Objective: To investigate the serum level of vascular endothelial growth factor(VEGF) and its clinical value in patients with esophageal cancer and stomach cancer. Methods: ELISA method was used to study the serum VEGF level in 37 esophageal neoplasm patients, 31 stomach neoplasm patients and 15 normal adults. Results: The serum VEGF level in two kinds of tumor patients was remarkably higher than in normal controls (P<0.01). It had a significant association with clinicopathologic features (invasion depth, lymph node metastasis and TNM stage). Conclusion: The expression of VEGF plays a key role in invasion and metastasis of esophageal neoplasms and gastric carcinoma, and serum VEGF level may serve as a indicator of progression and prognosis of these diseases.

关 键 词：内皮 血管生长因子 食管肿瘤 胃肿瘤 

分 类 号：R735.1[医药卫生—肿瘤] R735.2[医药卫生—临床医学]