3-巯基-4-氧代戊基乙酸酯的合成和机理探讨  

A Proposed Mechanism and Synthesis Of 3-Mercapto-4-oxopentyl Acetate

作　　者：王列平[1] 丁秀丽[1] 刘敏[1] 王作全[1] 

机构地区：[1]西安近代化学研究所,陕西西安710065

出　　处：《精细化工中间体》2004年第5期34-35,共2页Fine Chemical Intermediates

摘　　要：以α-乙酰基-γ-丁內酯为原料,经氯化、开环、脱羧、酯化和硫氢化钠的亲核取代合成3-巯基-4-氧代戊基乙酸酯,含量97%,总收率为75%。对它的合成机理进行了初步探讨。3-Mercapto-4oxoqentyl acetate was synthesized from α-acetyl-γ-butanolide by chlorization 、cleavage of ring 、decarboxylation、esterification and nucleophilic subtituent of sodium sulfhydride ,the purity reaches 97%,the overall yield is 75%。The compound is an important intermediate in synthesizing Vitamin B_ 1。Its synthetic mechanism was proposed in the essay.

关 键 词：α-乙酰基-γ丁-内酯 3-巯基-4-氧代戊基乙酸酯 合成 合成机理 

分 类 号：TQ225.2[化学工程—有机化工]