托吡酯联合用药治疗婴幼儿重症癫癎  

Study on topiramate as add-on drug treating severe epilepsy in infants

作　　者：郭异珍[1] 郑光荣[2] 姚丹[3] 

机构地区：[1]中国医学科学院 [2]中国协和医科大学 [3]北京协和医院儿科,北京100730

出　　处：《实用儿科临床杂志》2004年第11期986-987,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的 评价托吡酯(TPM)联合用药治疗婴幼儿重症癫痫的疗效及安全性。方法 对12例重症癫痫婴幼儿(年龄4～19个月)采用TPM联合用药治疗。TPM应用是根据发作形式和频率在原来一个或多个抗癫痫药物的基础上进行联合用药治疗。结果 TPM的起始剂量0．5～1．0mg／(kg·d)，加量1次／1～2周，剂量为0．5～1．0mg／(kg·d)，目标剂量为4～10mg／(kg·d)。TPM治疗时间平均为6．2个月，总有效率75％，无效率25％，完全控制为50％。临床观察局灶性发作疗效明显优于全面性强直一阵挛发作。TPM不良反应较轻，仅3例出现睡眠减少、发热及语言减少。结论 TPM联合用药治疗婴儿重症癫痫有效率较高，是一种安全性好、不良反应轻的治疗方法。Objective To evaluate the efficacy and safety of topiramate(TPM) as add - on drug treating infants with severe epilepsy. Methods We performed prospective label add - on study in 12 infants (aged 4 to 19 months) with sever seizures of different types. TPM was add - on one or more other baseline drugs and the efficacy was evaluated according to seizure type and frequency Results TPM initiated in a daily dose of 0.5 - 1 0 mg/kg, followed by a 1 - 2 weeks titration on the increase of 0 5 - 1.0 mg/kg up to a maximum daily dose of 4 - 10 mg/kg. After a mean period of 6 2 months (range 3- 13 montks), Total efficacy was 75 % and 50 % were controlled completely. Seizure frequency was unchanged in 3 patients (25 % ). As for seizure type, TPM was more effective in complex partial as compared with generalized tonic-conic seizures. Mild adverse events were present in 3 patients (25 %), represented hypersonia, fever and decreased speech. Conclusions TPM may be a available drug in infants with severe epilepsy. It is safe, with mild adverse effect in fewer patients.JAppl Clin Pediatr,2004,19(11):986-987

关 键 词：托吡酯 儿童 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]