Caveolae/Caveolins与病毒感染  

Caveolae/Caveolins and Virus Infection

作　　者：罗迪贤[1] 杨慧龄[1] 廖端芳[1] 万艳平[2] 

机构地区：[1]南华大学药物药理研究所,衡阳421001 [2]南华大学病原生物研究所,衡阳421001

出　　处：《生理科学进展》2004年第4期321-324,共4页Progress in Physiological Sciences

基　　金：国家自然科学基金资助课题 (39970 84 7)

摘　　要：Caveolae是直径为 5 0～ 10 0nm的细胞表面特异性内陷结构 ,Caveolins是它的主要标志蛋白。Caveolae/Caveolins在许多生理、病理活动中起重要作用。近年来还发现 ,Caveolae/Caveolins介导了许多病毒的感染 ,参与了病毒的吸附、穿入、转运、生物合成、组装及出泡等环节。这一病毒感染途径的发现 ,有助于抗病毒新药的开发和肿瘤治疗新领域的开辟。Caveolae, whose major structural proteins ar e Caveolins, are classically defined as flask-shaped plasma membrane invaginati ons with a characteristic diameter of 50 to 100 nm. Caveolae/Caveolins play impo rtant roles in many physiological and pathological activities. In recent years, Caveolae/Caveolins were found to associate with the absorption, entry, trafficki ng, replication, assembly and budding for many viruses. This route helps break a new pathway to the exploitation of new antiviral drugs and the prevention and t reatment of tumors.

关 键 词：CAVEOLAE Caveolins 病毒 感染 

分 类 号：Q939.4[生物学—微生物学]