蛇毒的抗肿瘤活性成分研究进展  

Progresses on antitumor effect of snake venom active components

作　　者：李晓红[1] 蔡绍晖[1] 任先达[1] 

机构地区：[1]暨南大学药学院药代动力学教研室,广东广州510632

出　　处：《中国病理生理杂志》2004年第10期1938-1941,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目 (No .39770 30 0 )

摘　　要：Many snake venoms contain complex mixtures of pharmacologically important molecules, some of which show potential therapeutic value in the treatment of cancer and other human disorders. In this review, we mainly reports the effects of snake venom active components, such as disintegrins and lectins in paralyzing cancer cells, blocking on cell migration, interaction with integrins, inhibition of tumor dissemination and angiogenesis. The advanced researches on the snake venom’s apoptosis-inducing components on tumors are also introduced. [Many snake venoms contain complex mixtures of pharmacologically important molecules, some of which show potential therapeutic value in the treatment of cancer and other human disorders. In this review, we mainly reports the effects of snake venom active components, such as disintegrins and lectins in paralyzing cancer cells, blocking on cell migration, interaction with integrins, inhibition of tumor dissemination and angiogenesis. The advanced researches on the snake venom's apoptosis-inducing components on tumors are also introduced. [

关 键 词：蛇毒液类 粘连 血管生成 病理性 细胞凋亡 肿瘤 

分 类 号：R363[医药卫生—病理学]