急性脑血管病患者心肌酶谱的变化及意义  

Study of Changes and Clinical Significances in Serum Myocardial Zymogram of Acute Cerebrovascular Disease

作　　者：陈小娟[1] 李君良[1] 赵斌[1] 

机构地区：[1]广东医学院附属医院检验科,524001

出　　处：《齐齐哈尔医学院学报》2004年第3期248-249,共2页Journal of Qiqihar Medical University

摘　　要：目的　探讨急性脑血管病患者血清心肌酶谱的变化及意义。方法　于发病 7天内用岛津CL72 0 0全自动生化分析仪检测 2 5 5例急性脑血管病患者血清天冬氨酸氨基转移酶 (AST)、乳酸脱氢酶(LDH)、肌酸激酶 (CK)及α -羟丁酸脱氢酶 (α -HBD)等心肌酶谱 ,同时进行神经功能缺损程度评分(NIHSS) ,并和 179例门诊健康体检者进行对照分析。结果　急性脑血管病患者心肌酶谱各项检测指标与对照组比较显著升高 ,P <0 .0 1;脑出血组和脑梗死组的血清心肌酶谱比较无统计学意义 ,P >0 .0 5 ;NIHSS高分组心肌酶谱水平高于低分组 ,P <0 .0 1;恢复期明显低于急性期 ,P <0 .0 1或P <0 .0 5。结论　急性脑出血患者表现心肌酶谱异常 ,和病情及病程相关 ,其意义有待进一步研究。Objective To observe the changes and clinical significances of serum myocardial zymogram in patients with acute cerebrovascular disease. Methods To estimate the serum myocardial zymogram which included Aspartate aminotransferase (AST), Lactate dehydrogenase (LDH), Creatine kinase (CK), and α-hydroxybutyrate dehydrogenase (α-HBD) of 255 patients with acute cerebrovascular disease in 7 days,and to assess their neurologic impairment by the NIHSS at the same time.Then to make comparison with 179 controls. Results The serum myocardial zymogram of acute cerebrovascular disease group were significantly higher than that of controls,P<0.01;but there was no significant difference between cerebral hemorrhage group and cerebral infarction group,P>0.05.In the group with higher NIHSS the serum myocardial zymogram level were higher than that of one with lower NIHSS, P< 0.01;In the acute period with cerebrovascular disease,its acute periods were higher than that in the recovery period,P<0.01 or P<0.05.Conclusions The study demonstrates the serum myocardial zymogram is abnormal in patients with acute cerebrovascular disease, and is related to the patient's condition or the course of disease,its value need to be researched further.

关 键 词：急性脑血管病 心肌酶谱 脑梗死 脑出血 心肌细胞 

分 类 号：R743[医药卫生—神经病学与精神病学]