17-β-雌二醇诱发大鼠腺垂体催乳素瘤的形成及原癌基因c-myc的高表达  

The Induction of Rat Prolactinoma by β-Estradiol and Its Relation to the Expression of Oncogene c-myc

作　　者：许荣焜[1] 郭传海[1] 黄曼影[1] 韩小四[1] 周远征[1] 单惠敏[1] 黄醒亚[1] 

机构地区：[1]中国医学科学院基础医学研究所生理研究室,北京100005

出　　处：《基础医学与临床》1993年第3期29-32,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(编号:39270286)

摘　　要：给SD大鼠皮下埋植17-β-雌二醇,60天后,其垂体重量显著增加;垂体前叶细胞明显增生,分化受抑制;用放射免疫法测定血浆催乳素含量显著增加;斑点杂交显示垂体细胞原癌基因c-myc的转录水平也显著增加。Spague-Daw ley rats were implanted with silastic capsules containing β-estradiol. After 60 days, their weights of pituitary, prolactin contents of ser urn and transcription level of proto-oncogene c-myc were increased significantly.It was also found that the cells of the anterior pituitary gland proliferated significantly, but their differentiation were suppressed.

关 键 词：Β-雌二醇 垂体瘤 催乳素 

分 类 号：R739.41[医药卫生—肿瘤]