纳洛酮对急性高原性脑水肿治疗效果的临床研究  

Therapeutic Effect of Naloxone on Acute High Altitude Brain Edema

作　　者：候明[1] 吕荣华[1] 

机构地区：[1]青海医学院附属医院急救中心,810001

出　　处：《青海医药杂志》2004年第7期6-7,共2页Qinghai Medical Journal

摘　　要：目的 :研究纳洛酮对急性高原性脑水肿的临床治疗效果。方法 :2 0例急性高原性脑水肿患者随机分为纳酪酮组和对照组 ,疗程 5天 ,每 1天、3天、5天予两组患者行脑脊液压力测定 ,并用TCD测量颈动脉平均血流速度和平均血流量及进行GCS评分 ,比较两组的变化。结果 :纳洛酮组治疗后颅内压明显降低 ,颈动脉平均血流速度及平均血流量明显增加 ,GCS评分明显升高。以上指标与对照组相比差别有显著性 (P <0 .0 5 )。结论 :纳洛酮治疗急性高原性脑水肿具有良好的疗效。Objective: To observe the therapeutic effect of naloxone on acute high altitude brain edema (AHABE). Method: A total of 20 patients with AHABE were randomly designed in the naloxine group and control group. The pressure of CSF was measured in the 1st, 2nd and third day; the mean velocity and volume of blood flow of carotid were recorded by TCD. The GCS estimation was performed.Result: The intracranial hypotension was remarkable and the carotid velocity and volume of blood flow were increased significantly as well as the GCS (P<0.05) in naloxone group compared with those in the control group. Conclusion: There is better therapeutic effect of naloxone on AHABE.

关 键 词：急性 脑水肿 纳洛酮 高原 GCS评分 对照组 平均血流速度 增加 指标 目的 

分 类 号：R743[医药卫生—神经病学与精神病学] R651[医药卫生—临床医学]