P_(16)和Cyclin D_1在皮肤鳞状细胞癌中的表达及意义  

Expression of p16 and cyclin D_1 in squamous cell carcinoma

作　　者：王丹[1] 曹军[1] 

机构地区：[1]广东医学院附属医院,湛江524001

出　　处：《广西医学》2004年第10期1433-1434,共2页Guangxi Medical Journal

摘　　要：目的　探讨P16和cyclinD1在皮肤鳞状细胞癌中的异常表达及与生物学行为的关系。方法　应用免疫组化S -P法检测 5 8例皮肤鳞状细胞癌中 p16和cyclinD1的表达水平。结果　 5 8例皮肤鳞状细胞癌中 p16和cyclinD的阳性表达率分别为 6 9%和 5 3.4 %。结论　p16和cyclinD1的异常表达在皮肤鳞状细胞癌的发生发展中起重要作用 ,可作为判断恶性程度 ,评估预后的指标。Objective To study the p16 and cyclin D 1 protein expression in squamous cell carcinoma and its significance in assessment of biological behavior.Methods The immunohistochemical staining method was used to evaluate the positivity of p16 and cyclin D 1 in 58 cases of squamous cell carcinoma.Results The positive rate of p16 and cyclin D 1 were 69% and 53.4%.Conclusion The abnormal expressions of P16 and cyclin D 1 play important roles in occurrence and development of the squamous cell carcinoma. Onogene proteins might be served as indicators to predict the malignant degree and the prognosis of squamous cell carcinoma.

关 键 词：皮肤鳞状细胞癌 CYCLIND1 异常表达 阳性表达率 恶性程度 发生发展 免疫组化S-P法 结论 意义 重要作用 

分 类 号：R739.5[医药卫生—肿瘤] R735[医药卫生—临床医学]