甘肃黄芩抗氧化有效成分的分离鉴定  

Isolation and elucidation of antioxidant constituents from acet one extract in root of Scutellaria rehderiana

作　　者：苏亚伦[1] 黄聿[2] 陈振宇[3] 

机构地区：[1]中国医学科学院药物研究所,北京100050 [2]香港中文大学生理系 [3]香港中文大学生物化学系

出　　处：《中国中药杂志》2004年第9期863-864,共2页China Journal of Chinese Materia Medica

摘　　要：目的 :分离鉴定甘肃黄芩丙酮提取物的抗氧化有效成分。方法 :采用色谱柱进行分离 ,以波谱及标准品方法鉴定化合物的结构。结果 :从丙酮提取物中分离得到了 5个化学成分 ,分别为千层纸素A(oroxylinA ,Ⅰ )、汉黄芩素 (wogonin ,Ⅱ )、黄芩素 (baicalein ,Ⅲ )、甘黄芩苷元 (ganhuangenin ,Ⅳ )、甘黄芩素 (ganhuangemin ,Ⅴ )。从甲醇提取物得到黄芩苷 (baicalin ,Ⅵ )。结论 :甘黄芩素 (ganhuangemin)为首次从甘肃黄芩中分离得到的二氢黄酮醇类化合物 ,黄芩素和甘黄芩苷元有较强的抗氧化活性 ,明显的高于BHT(butylatedhydroxytoluene)的抗氧化活性。Objective: To isolatate and elucidate the an tioxidant constituents from acetone extract of Scutellaria rehderiana. Method: Chemical constituents were isolated by several column c hromatographies and their structures were elucidated on the basis of standard co mpounds and spectral analysis. Result: Five compounds, oro xylin A, wogonin, baicalein, ganhuangenin, ganhuangemin were isolated from aceto ne extract of S. rehderiana. Baicalin was obtained from methanol extract of S. rehderiana. Conclusion: Ganhuangemin was isolated f rom the plant for the first time. Baicalein and ganhuangenin have stronger antio xidant activity than that of BHT (butylated hydroxytoluene).[

关 键 词：汉黄芩素 黄芩苷元 有效成分 抗氧化活性 首次 甲醇提取物 标准品 分离鉴定 丙酮提取物 BHT 

分 类 号：R284.1[医药卫生—中药学]